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Full-Text Articles in Psychology
Identification Of A Core Amino Acid Motif Within The Α Subunit Of Gabaars That Promotes Inhibitory Synaptogenesis And Resilience To Seizures, Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, Stephen J. Moss
Identification Of A Core Amino Acid Motif Within The Α Subunit Of Gabaars That Promotes Inhibitory Synaptogenesis And Resilience To Seizures, Anna J. Nathanson, Yihui Zhang, Joshua L. Smalley, Thomas A. Ollerhead, Miguel A. Rodriguez Santos, Peter M. Andrews, Heike J. Wobst, Yvonne E. Moore, Nicholas J. Brandon, Rochelle M. Hines, Paul A. Davies, Stephen J. Moss
Psychology Faculty Research
The fidelity of inhibitory neurotransmission is dependent on the accumulation of γ-aminobutyric acid type A receptors (GABAARs) at the appropriate synaptic sites. Synaptic GABAARs are constructed from α(1-3), β(1-3), and γ2 subunits, and neurons can target these subtypes to specific synapses. Here, we identify a 15-amino acid inhibitory synapse targeting motif (ISTM) within the α2 subunit that promotes the association between GABAARs and the inhibitory scaffold proteins collybistin and gephyrin. Using mice in which the ISTM has been introduced into the α1 subunit (Gabra1-2 mice), we show that the ISTM is critical for axo-axonic synapse formation, the efficacy of GABAergic …
Training To Inhibit Negative Content Affects Memory And Rumination, Shimrit Daches, Nilly Mor, Paula T. Hertel
Training To Inhibit Negative Content Affects Memory And Rumination, Shimrit Daches, Nilly Mor, Paula T. Hertel
Psychology Faculty Research
Depressive rumination, the tendency to engage in repetitive self-focus in response to distress, seems to be affected by a variety of cognitive biases that in turn maintain negative emotional states. The current study examined whether the difficulty in inhibiting attention to negative information contributes to rumination and to rumination-related biases in memory. Seventy-nine ruminators underwent a 3-week computer-based training, designed to increase either inhibition of negative words or attention to them. On immediate post-training trials, as well as on 2-week follow-up tests, we found evidence for transfer of inhibition training. Training effects also occurred on session-by-session and post-training measures of …
Distracted By Cues For Suppressed Memories, Paula T. Hertel, Jeffrey A. Hayes
Distracted By Cues For Suppressed Memories, Paula T. Hertel, Jeffrey A. Hayes
Psychology Faculty Research
We examined the potential cost of practicing suppression of negative thoughts for subsequent performance in an unrelated task. Cues for previously suppressed and baseline responses in a think/no-think procedure were displayed as irrelevant flankers for neutral words to be judged for emotional valence. These critical flankers were homographs with one negative meaning denoted by their paired responses during learning. Suppression cues as flankers delayed responding to the targets, compared to baseline cues and new negative homographs, but only following direct-suppression instructions and not when benign substitutes had been provided to aid suppression. On the final recall test, suppression-induced forgetting (SIF) …
Rumination: Cognitive Consequences Of Training To Inhibit The Negative, Shimrit Daches, Nilly Mor, Paula T. Hertel
Rumination: Cognitive Consequences Of Training To Inhibit The Negative, Shimrit Daches, Nilly Mor, Paula T. Hertel
Psychology Faculty Research
Background and Objectives: To explore cognitive factors in ruminative thinking, we assessed the effect of a single-session of inhibition training on subsequent biases in attention and interpretation.
Methods: We randomly assigned participants to either inhibit or attend to negative stimuli. Inhibition was assessed by using assessment trials embedded throughout the training, and interpretation bias was assessed following the training.
Results: Trait rumination moderated training effects on both measures. Low ruminators in the inhibition-training condition maintained their level of inhibition of negative stimuli, but those in the attention-training condition showed a non-significant trend for decreased inhibition. Participants also …
Suppression-Induced Forgetting On A Free-Association Test, Paula T. Hertel, Daniel Large, Ellen Stuck, Allison Levy
Suppression-Induced Forgetting On A Free-Association Test, Paula T. Hertel, Daniel Large, Ellen Stuck, Allison Levy
Psychology Faculty Research
The repeated suppression of thoughts in response to cues for their expression leads to forgetting on a subsequent test of cued recall (Anderson & Green, 2001). We extended this effect by using homograph cues and presenting them for free association following suppression practice. Cue-target pairs were first learned under integrating imagery instructions; then in the think/no-think phase students practiced suppressing thoughts connected to some homograph cues, with or without the assistance of thought substitutes that changed their meaning. Below-baseline forgetting on the subsequent free-association test was found in the production of suppressed targets. Following aided suppression, this effect was also …
Impairments In Inhibition Or Cognitive Control In Psychological Disorders, Paula T. Hertel
Impairments In Inhibition Or Cognitive Control In Psychological Disorders, Paula T. Hertel
Psychology Faculty Research
Contributions to this special issue of Applied & Preventive Psychology richly elucidate connections between a variety of psychological disorders and performance in a number of tasks that are used to reason about inhibitory deficits. This commentary calls attention to the different uses of the concept of inhibition - vernacular, neural, operational, and theoretical - and suggests that the term cognitive control avoids claims about dampened memory representations that are difficult to support. Central findings from the reviews are summarized; evidence concerning suppression-induced forgetting is featured and directions to foster application are discussed.
Memory For Emotional And Nonemotional Events In Depression: A Question Of Habit?, Paula T. Hertel
Memory For Emotional And Nonemotional Events In Depression: A Question Of Habit?, Paula T. Hertel
Psychology Faculty Research
The truest claim that cognitive science can make might also be the least sophisticated: the mind tends to do what it has done before. In previous centuries philosophers and psychologists invented constructs such as associations, habit strength, and connectivity to formalize the truism, but others have known about it, too. In small towns in the Ozarks, for example, grandmothers have been overheard doling out warnings such as, "Don't think those ugly thoughts; your mind will freeze that way." Depressed persons, like most of us, usually don't heed this advice. The thoughts frozen in their minds might not be "ugly," but …