Psychology Commons^™

Selective Breeding For Differential Saccharin Intake As An Animal Model Of Drug Abuse., M. E. Carroll, A. D. Morgan, J. J. Anker, J. L. Perry, Nancy K. Dess

Nancy K Dess

A positive relationship between the consumption of sweetened dietary substances (e.g. saccharin and sucrose) and drug abuse has been reported in both the human and other animal literature. The proposed genetic contribution to this relationship has been based on evidence from behavioral, neurobiological, and linkage studies in heterogeneous and homogeneous animal populations. Initial work in several laboratories indicated that rodents that are selected for high alcohol consumption also display an increased preference for sweets compared with low alcohol-consuming animals. More recently, Sprague-Dawley rats have been selectively bred based on high saccharin (HiS) or low saccharin (LoS) consumption, and these lines …