Psychology Commons^™

Functional Interplay Between Neurocognitive Decline And Risk Factors In Older Adults: A Multivariate Latent Growth Curve Model Of Risk, Rebecca Kathryn Macaulay

LSU Doctoral Dissertations

Alzheimer’s disease (AD) is a heterogeneous brain disease with multiple interacting risk factors, suggesting equifinality. Research indicates that the pathophysiological processes involved in AD are evident years prior to disease onset with significant variability in neurocognitive functioning being apparent during preclinical stages. Identification of individuals in preclinical stages is vital, as earlier interventions may prove more effective at ameliorating AD’s devastating effects. In this respect, clarifying relationships between risk factors and neurocognitive functioning in cognitively intact older adults can improve our understanding of mechanisms involved in preclinical AD, which may allow for earlier detection and intervention. The present study employed …