Psychology Commons^™

The Effect Of Chronic Ethanol On Vta Gaba Neurons, Stephanie Bair, Scott Steffensen

Journal of Undergraduate Research

The current accepted model for addiction in the brain is the dysregulation of dopamine (DA) in the mesolimbic pathway, which begins in the ventral tegmental area (VTA) and projects to the nucleus accumbens (NAc). DA neurons originate in the VTA and project to the NAc where they release DA. Dopamine neurons are typically regulated locally by inhibitory gamma-aminobutyric acid (GABA) neurons in the VTA. Because GABA neurons in the VTA regulate DA neurons, we conclude that changes in VTA GABA neurons will affect DA release in the NAc underlying addictive behaviors, especially reward seeking.