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Full-Text Articles in Psychology
Chlordiazepoxide Increases Risky Choice, Devin Andrew Galdieri
Chlordiazepoxide Increases Risky Choice, Devin Andrew Galdieri
Graduate Theses, Dissertations, and Problem Reports
Probability discounting is a measure of risky choice that is correlated with maladaptive behavior and psychological disorders. Benzodiazepines are a class of drug on which relatively little risky-choice research has been conducted, particularly under conditions of chronic drug exposure. Chlordiazepoxide, a standard benzodiazepine, was administered to rats that had been trained to respond on a risky-choice task in which a choice was available between a single food pellet with 100% certainty or three food pellets with probabilities of delivery that decreased across each experimental session. During baseline, responding was sensitive to the programmed contingencies and larger-reinforcer choice decreased as the …
Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Minocycline As A Treatment For Traumatic Brain Injury-Induced Impulsive And Attentional Deficits, Kristen M. Pechacek
Graduate Theses, Dissertations, and Problem Reports
Traumatic brain injury (TBI) impacts millions worldwide and can cause lasting psychiatric symptoms. Chronic neuroinflammation is a characteristic of post-injury pathology and is positively associated with psychiatric conditions such as ADHD and bipolar disorder. Therefore, the current study sought to treat TBI-induced impulsivity and inattention using minocycline, an antibiotic with anti-inflammatory properties. Rats were trained on the five-choice serial reaction time task (5CSRT), a measure of motor impulsivity and attention. After behavior was stable on the 5CSRT, rats received either a bilateral frontal TBI or sham procedure. Minocycline was given at either 1 h post-injury or beginning at 8 weeks …