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Full-Text Articles in Psychology
Oprm1 Gene Variation Influences Hypothalamic-Pituitary-Adrenal Axis Function In Response To A Variety Of Stressors In Rhesus Macaques, Melanie L. Schwandt, Stephen G. Lindell, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr
Oprm1 Gene Variation Influences Hypothalamic-Pituitary-Adrenal Axis Function In Response To A Variety Of Stressors In Rhesus Macaques, Melanie L. Schwandt, Stephen G. Lindell, James Dee Higley, Stephen J. Suomi, Markus Heilig, Christina S. Barr
Faculty Publications
The endogenous opioid system is involved in modulating a number of behavioral and physiological systems, including the hypothalamic-pituitary-adrenal (HPA) axis. In humans, a functional variant in the OPRM1 gene (OPRM1 A118G) is associated with a number of outcomes, including attenuated HPA axis responses to stress. A nonsynonymous variant (OPRM1 C77G) in the rhesus macaque has been shown to have similar effects in vivo to the human variant. The current study investigated whether OPRM1 C77G influences HPA axis response to stress in rhesus macaques. We analyzed plasma adrenocorticotropic hormone (ACTH) and cortisol levels measured in response to three different stressors: 1) …