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Postseptic Cognitive Impairment And Expression Of Apoe In Peripheral Blood: The Cognition After Sepsis (Cass) Observational Pilot Study, Samuel M. Brown, Sarah J. Beesley, Chris Stubben, Emily L. Wilson, Angela P. Presson, Colin Grissom, Colin Maguire, Matthew T. Rondina, Ramona O. Hopkins
Postseptic Cognitive Impairment And Expression Of Apoe In Peripheral Blood: The Cognition After Sepsis (Cass) Observational Pilot Study, Samuel M. Brown, Sarah J. Beesley, Chris Stubben, Emily L. Wilson, Angela P. Presson, Colin Grissom, Colin Maguire, Matthew T. Rondina, Ramona O. Hopkins
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Background: Cognitive impairment after sepsis is an important clinical problem. Determinants of postseptic cognitive impairment are not well understood. We thus undertook a systems biology approach to exploring a possible role for apolipoprotein E (APOE) in postseptic cognitive impairment.
Design: Prospective, observational cohort. Setting: Intermountain Medical Center, a tertiary referral center in Utah.
Patients/Participants: Patients with sepsis admitted to study intensive care units. Interventions: None.
Methods: We obtained peripheral blood for deep sequencing of RNA and followed up survivors at 6 months with a battery of cognitive instruments. We defined cognitive impairment based on the 6-month Hayling test of executive …