Psychology Commons^™

Early Rearing History Influences Oxytocin Receptor Epigenetic Regulation In Rhesus Macaques, Maggie Baker, Stephen G. Lindell, Carlos A. Driscoll, Zhifeng Zhou, Qiaoping Yuan, Melanie L. Schwandt, Isaac Miller-Crews, Elizabeth A. Simpson, Annika Paukner, Pier Francesco Ferrari, Ravi Kumar Sindhu, Muslima Razaqya, Wolfgang H. Sommer, Juan F. Lopez, Robert C. Thompson, David Goldman, Markus Heilig, J. Dee Higley, Stephen J. Suomi, Christina S. Barr

Faculty Publications

Adaptations to stress can occur through epigenetic processes and may be a conduit for informing offspring of environmental challenge. We employed ChIP-sequencing for H3K4me3 to examine effects of early maternal deprivation (peer-rearing, PR) in archived rhesus macaque hippocampal samples (male, n = 13). Focusing on genes with roles in stress response and behavior, we assessed the effects of rearing on H3K4me3 binding by ANOVA. We found decreased H3K4me3 binding at genes critical to behavioral stress response, the most robust being the oxytocin receptor gene OXTR, for which we observed a corresponding decrease in RNA expression. Based on this finding, we …

Preadolescent Sensation Seeking And Early Adolescent Stress Relate To At-Risk Adolescents' Substance Use By Age 15, Nora E. Charles, Charles W. Mathias, Ashley Acheson, Donald M. Dougherty

Faculty Publications

Background and aims

Substance use during adolescence can lead to the development of substance use disorders and other psychosocial problems. These negative outcomes are especially likely for individuals who use substances at earlier ages and those who engage in heavier use during adolescence, behaviors which are both more common among youth at higher risk for developing a substance use disorder, such as those with a family history of substance use disorders (FH +). Factors such as increased sensation seeking and greater exposure to stressors among FH + youth may influence these associations. Therefore, the aim of this study was to …