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Full-Text Articles in Psychology
Cognitive Impact Of Genetic Variation Of The Serotonin Transporter In Primates Is Associated With Differences In Brain Morphology Rather Than Serotonin Neurotransmission, Hank P. Jedema, Peter J. Gianaros, Phillip J. Greer, Dustin D. Kerr, Shijing Liu, James Dee Higley, Stephen J. Suomi, Adam S. Olsen, Jessica N. Porter, Brian J. Lopresti, Ahmad R. Hariri, Charles W. Bradberry
Cognitive Impact Of Genetic Variation Of The Serotonin Transporter In Primates Is Associated With Differences In Brain Morphology Rather Than Serotonin Neurotransmission, Hank P. Jedema, Peter J. Gianaros, Phillip J. Greer, Dustin D. Kerr, Shijing Liu, James Dee Higley, Stephen J. Suomi, Adam S. Olsen, Jessica N. Porter, Brian J. Lopresti, Ahmad R. Hariri, Charles W. Bradberry
Faculty Publications
A powerful convergence of genetics, neuroimaging and epidemiological research has identified biological pathways mediating individual differences in complex behavioral processes and related risk for disease. Orthologous genetic variation in non-human primates represents a unique opportunity to characterize the detailed molecular and cellular mechanisms which bias behaviorally- and clinically-relevant brain function. We report that a rhesus macaque orthologue of a common polymorphism of the serotonin transporter gene (rh5-HTTLPR) has strikingly similar effects on behavior and brain morphology to those in humans. Specifically, the rh5- HTTLPR Short allele broadly impacts cognitive choice behavior and brain morphology without observably affecting 5-HT transporter or …