Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Psychology
Quantitative Template For Subtyping Primary Progressive Aphasia, Marsel Mesulam, Christina Wieneke, Emily Rogalski, Derin J. Cobia, Cynthia Thompson, Sandra Weintraub
Quantitative Template For Subtyping Primary Progressive Aphasia, Marsel Mesulam, Christina Wieneke, Emily Rogalski, Derin J. Cobia, Cynthia Thompson, Sandra Weintraub
Faculty Publications
Objective—To provide a quantitative algorithm for classifying primary progressive aphasia (PPA) into agrammatic (PPA-G), semantic (PPA-S) and logopenic (PPA-L) variants, each of which is known to have a different probability of association with Alzheimer’s disease (AD) versus frontotemporal lobar degeneration (FTLD).
Design—Prospectively and consecutively enrolled 16 PPA patients tested with neuropsychological instruments and magnetic resonance imaging (MRI).
Setting—University medical center. Participants—PPA patients recruited nationally in the USA as part of a longitudinal study.
Results—A two-dimensional template, reflecting performance on tests of syntax (Northwestern Anagram Test) and lexical semantics (Peabody Picture Vocabulary Test), classified all 16 patients in concordance with a …