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Full-Text Articles in Psychology
Association Between Toxoplasma Gondii Seropositivity And Memory Function In Non-Demented Older Adults, Cynthia Elizabeth Wyman, Shawn D. Gale, Ariana Hedges-Muncy, Lance D. Erickson, Eric Wilson, Dawson W. Hedges
Association Between Toxoplasma Gondii Seropositivity And Memory Function In Non-Demented Older Adults, Cynthia Elizabeth Wyman, Shawn D. Gale, Ariana Hedges-Muncy, Lance D. Erickson, Eric Wilson, Dawson W. Hedges
Faculty Publications
Toxoplasma gondii (T. gondii) seropositivity may be associated with decreased memory in older adults. To further investigate the association between T. gondii seropositivity and memory in nondemented older adults, we obtained serum samples from 114 non-demented older adults evaluated by the Alzheimer’s Disease and Research Center at Washington University in St. Louis Missouri, USA. We determined T. gondii seropositivity and anti-T. gondii IgG antibody titer and examined associations with memory function while controlling for socioeconomic status, education level, age, and apolipoprotein E4 status. There were few associations between T. gondii seropositivity or anti-T. gondii IgG antibodies and memory, although there …
Toxoplasma Gondii Moderates The Association Between Multiple Folate-Cycle Factors And Cognitive Function In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Toxoplasma Gondii Moderates The Association Between Multiple Folate-Cycle Factors And Cognitive Function In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Toxoplasma gondii (T. gondii) is a microscopic, apicomplexan parasite that can infect muscle or neural tissue, including the brain, in humans. While T. gondii infection has been associated with changes in mood, behavior, and cognition, the mechanism remains unclear. Recent evidence suggests that T. gondii may harvest folate from host neural cells. Reduced folate availability is associated with an increased risk of neurodevelopmental disorders, neurodegenerative diseases, and cognitive decline. We hypothesized that impairment in cognitive functioning in subjects seropositive for T. gondii might be associated with a reduction of folate availability in neural cells. We analyzed data from the third …
No Association Between Latent Toxoplasmosis And Multiple Body Measures In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
No Association Between Latent Toxoplasmosis And Multiple Body Measures In U.S. Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Toxoplasma gondii (Nicolle et Manceaux, 1908) is an intracellular parasite that can cause ongoing latent infection persisting for the duration of a non-definitive host's life. Affecting approximately one-third of the world's population, latent toxoplasmosis has been associated with neuropsychological outcomes and a previous report suggested an association between latent toxoplasmosis and adult height. Given the large number of people with latent toxoplasmosis and its potential associations with human height, we sought to better understand the association between latent toxoplasmosis and human morphology by evaluating seropositivity for T. gondii and multiple body measures reported in the National Health and Nutrition Examination …
No Association Between Current Depression And Latent Toxoplasmosis In Adults, Bruce L. Brown, Shawn D. Gale, Andrew N. Berrett, Lance D. Erickson, Dawson W. Hedges
No Association Between Current Depression And Latent Toxoplasmosis In Adults, Bruce L. Brown, Shawn D. Gale, Andrew N. Berrett, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Changes in behaviour and cognition have been associated with latent infection from the apicomplexan protozoan Toxoplasma gondii (Nicolle et Manceaux, 1908) in both animal and human studies. Further, neuropsychiatric disorders such as schizophrenia have also been associated with latent toxoplasmosis. Previously, we found no association between T. gondii immunoglobulin G antibody (IgG) seropositivity and depression in human adults between the ages of 20 and 39 years (n = 1 846) in a sample representative of the United States collected by the Centers for Disease Control as part of a National Health and Nutrition Examination Survey (NHANES) from three datasets collected …
Association Between Latent Toxoplasmosis And Major Depression, Generalised Anxiety Disorder And Panic Disorder In Human Adults, Shawn D. Gale, Bruce L. Brown, Andrew Berrett, Lance D. Erickson, Dawson W. Hedges
Association Between Latent Toxoplasmosis And Major Depression, Generalised Anxiety Disorder And Panic Disorder In Human Adults, Shawn D. Gale, Bruce L. Brown, Andrew Berrett, Lance D. Erickson, Dawson W. Hedges
Faculty Publications
Latent infection with the apicomplexan Toxoplasma gondii (Nicolle et Manceaux, 1908) has been associated with schizophrenia, bipolar disorder and self-harm behaviour. However, the potential relationship between T. gondii immunoglobulin G antibody (IgG) seropositivity and generalised-anxiety disorder (GAD) and panic disorder (PD) has not been investigated. The associations between serum reactivity to T. gondii and major depressive disorder (MDD), GAD and PD were evaluated in a total sample of 1 846 adult participants between the ages of 20 and 39 years from the United States Center for Disease Control's National Health and Nutrition Examination Survey (NHANES). Approximately 16% of the overall …