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Full-Text Articles in Psychology
Cannabis-Related Episodic Memory Deficits And Hippocampal Morphological Differences In Healthy Individuals And Schizophrenia Subjects, Derin J. Cobia, Matthew J. Smith, James L. Reilly, Jodi Gilman, Andrea G. Roberts, Kathryn I. Alpert, Lei Wang, Hans C. Breiter, John G. Csernansky
Cannabis-Related Episodic Memory Deficits And Hippocampal Morphological Differences In Healthy Individuals And Schizophrenia Subjects, Derin J. Cobia, Matthew J. Smith, James L. Reilly, Jodi Gilman, Andrea G. Roberts, Kathryn I. Alpert, Lei Wang, Hans C. Breiter, John G. Csernansky
Faculty Publications
Cannabis use has been associated with episodic memory (EM) impairments and abnormal hippocampus morphology among both healthy individuals and schizophrenia subjects. Considering the hippocampus' role in EM, research is needed to evaluate the relationship between cannabis-related hippocampal morphology and EM among healthy and clinical groups. We examined differences in hippocampus morphology between control and schizophrenia subjects with and without a past (not current) cannabis use disorder (CUD). Subjects group-matched on demographics included 44 healthy controls (CON), 10 subjects with a CUD history (CON-CUD), 28 schizophrenia subjects with no history of substance use disorders (SCZ), and 15 schizophrenia subjects with a …
Activity In Both Hippocampus And Perirhinal Cortex Predicts The Memory Strength Of Subsequently Remembered Information, Y. Schrager, C. Brock Kirwan, L. R. Squire
Activity In Both Hippocampus And Perirhinal Cortex Predicts The Memory Strength Of Subsequently Remembered Information, Y. Schrager, C. Brock Kirwan, L. R. Squire
Faculty Publications
An influential idea about memory and medial temporal lobe function suggests that hippocampal activity predicts subsequent recognition success only when decisions are based on recollection, whereas perirhinal activity predicts subsequent recognition success when decisions are based on familiarity. An alternative idea is that hippocampal and perirhinal activity are both sensitive to the level of overall memory strength. Using functional magnetic resonance imaging, we have tested the relationship between brain activity during learning and subsequent memory strength. Activity in a number of cortical regions (including regions within what has been termed the default network) was negatively correlated with subsequent memory strength, …
Conditional Discrimination And Reversal In Amnesia Subsequent To Hypoxic Brain Injury Or Anterior Communicating Artery Aneurysm Rupture, C. E. Myers, J. Deluca, Ramona O. Hopkins, M. A. Gluck
Conditional Discrimination And Reversal In Amnesia Subsequent To Hypoxic Brain Injury Or Anterior Communicating Artery Aneurysm Rupture, C. E. Myers, J. Deluca, Ramona O. Hopkins, M. A. Gluck
Faculty Publications
Human anterograde amnesia can develop following bilateral damage to the hippocampus and medial temporal lobes, as in hypoxic brain injury, or following damage to the basal forebrain, as following anterior communicating artery (ACoA) aneurysm rupture. In both cases, the mnestic deficit may be similar when assessed by standard neuropsychological measures. However, animal and computational models suggest that there are qualitative differences in the pattern of impaired and spared memory abilities following damage to hippocampus versus basal forebrain. Here, we show such a dissociation in human amnesia using a single two-stage task, involving conditional discrimination and reversal. Consistent with a prior …
Brain Integrity And Cerebral Atrophy In Vietnam Combat Veterans With And Without Posttraumatic Stress Disorder, Bruce L. Brown, Dawson W. Hedges, G. William Thatcher, Pamela J. Bennett, Shabnam Sood, David Paulson, Sarah Creem-Regehr, Steven Allen, Jamie Johnson, Brooke Froelich, Erin D. Bigler
Brain Integrity And Cerebral Atrophy In Vietnam Combat Veterans With And Without Posttraumatic Stress Disorder, Bruce L. Brown, Dawson W. Hedges, G. William Thatcher, Pamela J. Bennett, Shabnam Sood, David Paulson, Sarah Creem-Regehr, Steven Allen, Jamie Johnson, Brooke Froelich, Erin D. Bigler
Faculty Publications
Posttraumatic stress disorder (PTSD) is associated with decreased hippocampal volume, but the relationship between trauma and brain morphology in the absence of PTSD is less clear. In this study, measures of brain integrity were determined by estimating gray and white matter regional brain volumes using structural magnetic resonance imaging in six patients with PTSD and in five controls with comparable trauma exposure but without clinical evidence of PTSD. The only statistically significant volume difference between groups was observed multivariately in the white matter of the right temporal lobe (superior temporal gyrus, fusiform gyrus, parahippocampal gyrus, white-matter stem, middle temporal gyrus, …
The Hippocampus Supports Both The Recollection And The Familiarity Components Of Recognition Memory, Peter E. Wais, John T. Wixted, Ramona O. Hopkins, Larry R. Squire
The Hippocampus Supports Both The Recollection And The Familiarity Components Of Recognition Memory, Peter E. Wais, John T. Wixted, Ramona O. Hopkins, Larry R. Squire
Faculty Publications
The receiver operating characteristic (ROC) has been used to investigate the component processes of recognition memory. Some studies with this technique have been taken to indicate that the hippocampus selectively supports the process of recollection, whereas adjacent cortex in the parahippocampal gyrus supports the process of familiarity. We analyzed ROC data from young adults, memory-impaired patients with limited hippocampal lesions, and age-matched controls. The shape of the ROC changed in similar ways from asymmetric to symmetric, as a function of the strength of memory (strong to weak) in both the young adults and the patients. Moreover, once overall memory strength …