Psychology Commons^™

Parental Genetic Contributions To Neonatal Temperament In A Nonhuman Primate (Macaca Mulatta) Model, Elizabeth K. Wood, Jacob N. Hunter, Joseph A. Olsen, Laura Almasay, Stephen G. Lindell, David Goldman, Christina S. Barr, Stephen J. Suomi, Daniel B. Kay, James Dee Higley

Faculty Publications

Temperament is an individual’s nature and is widely believed to have a heritable foundation. Few studies, however, have evaluated paternal and maternal contributions to the triadic dimensions of temperament. Rhesus monkeys are widely utilized to model genetic contributions to human development due to their close genetic-relatedness and common temperament structure, providing a powerful translational model for investigating paternal and maternal genetic influences on temperament. The temperament of rhesus monkey infants born to 19 different sires and 50 different dams was assessed during the first month of life by comparing the temperament of paternal or maternal half-siblings reared with their mothers …

Thalamic Shape Abnormalities Differentially Relate To Cognitive Performance In Early-Onset And Adult-Onset Schizophrenia, Derin J. Cobia, Chaz Rich, Matthew J. Smith, Pedro Engel Gonzalez, Will Cronenwett, John G. Csernansky, Lei Wang

Faculty Publications

Early-onset schizophrenia (EOS) shares many biological and clinical features with adult-onset schizophrenia (AOS), but may represent a unique subgroup with greater susceptibility for disease onset and worsened symptomatology and progression, which could potentially derive from exaggerated neurodevelopmental abnormalities. Neurobiological explanations of schizophrenia have emphasized the involvement of deep-brain structures, particularly alterations of the thalamus, which have been linked to core features of the disorder. The aim of this study was to compare thalamic shape abnormalities between EOS and AOS subjects and determine whether unique behavioral profiles related to these differences. It was hypothesized abnormal thalamic shape would be observed in …

Maternal Depression Moderated By Family Resources When Children Have Developmental Disabilities., Timothy B. Smith, Terisa P. Gabrielsen

Faculty Publications

Children with developmental disabilities require extensive parental involvement in intervention, but parents with depression may be less able to intervene effectively. We examined prevalence of depression symptoms and predictors among 131 mothers of children with disabilities enrolled in early childhood special education. Participants completed several self-report measures of depression and child and family functioning. Children were directly evaluated using the Battelle Developmental Inventory. One year later, 68 mothers repeated self-report measures. Participants (30%) reported elevated depression symptoms across time. Depression scores were correlated with parental stress and family resources. An interaction between higher maternal depression and higher child functioning with …

Postseptic Cognitive Impairment And Expression Of Apoe In Peripheral Blood: The Cognition After Sepsis (Cass) Observational Pilot Study, Samuel M. Brown, Sarah J. Beesley, Chris Stubben, Emily L. Wilson, Angela P. Presson, Colin Grissom, Colin Maguire, Matthew T. Rondina, Ramona O. Hopkins

Faculty Publications

Background: Cognitive impairment after sepsis is an important clinical problem. Determinants of postseptic cognitive impairment are not well understood. We thus undertook a systems biology approach to exploring a possible role for apolipoprotein E (APOE) in postseptic cognitive impairment.

Design: Prospective, observational cohort. Setting: Intermountain Medical Center, a tertiary referral center in Utah.

Patients/Participants: Patients with sepsis admitted to study intensive care units. Interventions: None.

Methods: We obtained peripheral blood for deep sequencing of RNA and followed up survivors at 6 months with a battery of cognitive instruments. We defined cognitive impairment based on the 6-month Hayling test of executive …