Psychology Commons^™

Oprm1 Genotype Interacts With Serotonin System Dysfunction To Predict Alcohol-Heightened Aggression In Primates, Carlos A. Driscoll, Stephen G. Lindell, Melanie L. Schwandt, Stephen J. Suomi, J. Dee Higley, Markus Heilig, Christina S. Barr

Faculty Publications

Although the notion that alcohol promotes violence is widespread, not all individuals are aggressive while intoxicated. Genetic variation could be a contributing factor to individual differences in alcohol-heightened aggression. The present study examines the effects of OPRM1C77G genotype on responses to threat in rhesus macaques under normal conditions and following alcohol administration. Prior studies have shown that a low CSF level of 5-HIAA is a trait marker for individuals prone to escalated aggression. We wanted to examine whether the predictive value for this marker on aggression was moderated by OPRM1 genotype. Animals were administered alcohol (BAC 100-200 mg%), were provoked …

The Longitudinal Impact Of Screen Time On Adolescent Development: Moderation By Respiratory Sinus Arrhythmia, Wesley Sanders, Justin Parent, Jamie L. Abaied, Rex Forehand, Sarah M. Coyne, W. Justin Dyer

Faculty Publications

Purpose: To date, little is known about underlying psychophysiological contributions to the impact of media content and overall screen time on adolescent psychological functioning. In the present study we examine respiratory sinus arrhythmia (RSA) as a moderator of the link between specific types of media content use, overall media exposure, and the development of internalizing and aggressive symptoms in youth.

Methods: A sample of 374 adolescents (mean age = 15) reported on their media use, internalizing behavior, and aggressive behavior at time 1 (2011) and 1-year follow-up (2012). RSA reactivity was gathered during a challenging laboratory task. Path analyses were …

Toxoplasma Gondii Seropositivity And Substance Use In Us Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Evan L. Thacker, Dawson W. Hedges

Faculty Publications

The intracellular parasite Toxoplasma gondii (Nicolle et Manceaux, 1908) infects humans resulting in acute toxoplasmosis, an infection that in immunocompetent people is typically mild but results in persistent latent toxoplasmosis. In that T. gondii appears to affect dopamine synthesis and because addicting drugs affect midbrain dopamine transmission, latent toxoplasmosis could influence substance use. Using both the third and continuous National Health and Nutrition Examination Surveys from the US Centers for Disease Control and Prevention, we used logistic regression to test for associations between T. gondii seropositivity and subject self-report of having ever used tobacco, alcohol, marijuana, cocaine, heroin, or methamphetamine. …

Sex Differences In Rhesus Monkeys’ Digit Ratio (2d:4d Ratio) And Its Association With Maternal Social Dominance Rank, Alexander Baxter, Elizabeth K. Wood, Parker Jarman, Ashley N. Cameron, John P. Capitanio, James Dee Higley

Faculty Publications

Prenatal androgen exposure (PAE) plays a pivotal role in masculinizing the developing body and brain, and extreme exposure may contribute to autism, anxiety disorder and schizophrenia. One commonly used biomarker for PAE is the pointer-to-ring-finger digit length (2D:4D) ratio. Although this biomarker is widely used in human studies, relatively few studies have investigated 2D:4D ratio in nonhuman primates, particularly rhesus macaques (Macaca mulatta), one of the most commonly used animals in biomedical research. Thus far, data suggest that sexual dimorphism in 2D:4D ratio may be in the opposite direction in some monkey species, when compared to the pattern …

Advancing Social Connection As A Public Health Priority In The United States, Julianne Holt-Lunstad, Theodore Robles, David A. Sbarra

Faculty Publications

A robust body of scientific evidence indicates that being embedded in high-quality close relationships and feeling socially connected to the people in your life is associated with decreased risk for all-cause mortality as well as a range of disease morbidities. Despite mounting evidence that the magnitude of these associations is comparable to many leading health determinants (that receive significant public health resources), government agencies, healthcare providers and associations, and public/private healthcare funders are slow to recognize human social relationships as either a health determinant or health risk marker in a manner that is comparable to other public health priorities. This …

Tuning Out Security Warnings: A Longitudinal Examination Of Habituation Through Fmri, Eye Tracking, And Field Experiments, Anthony Vance, Jeffrey L. Jenkins, Bonnie Brinton Anderson, Daniel K. Bjornn, C. Brock Kirwan

Faculty Publications

Research in the fields of information systems and human-computer interaction has shown that habituation— decreased response to repeated stimulation—is a serious threat to the effectiveness of security warnings. Although habituation is a neurobiological phenomenon that develops over time, past studies have only examined this problem cross-sectionally. Further, past studies have not examined how habituation influences actual security warning adherence in the field. For these reasons, the full extent of the problem of habituation is unknown. We address these gaps by conducting two complementary longitudinal experiments. First, we performed an experiment collecting fMRI and eye-tracking data simultaneously to directly measure habituation …

Association Between Toxoplasma Gondii Seropositivity And Memory Function In Non-Demented Older Adults, Cynthia Elizabeth Wyman, Shawn D. Gale, Ariana Hedges-Muncy, Lance D. Erickson, Eric Wilson, Dawson W. Hedges

Faculty Publications

Toxoplasma gondii (T. gondii) seropositivity may be associated with decreased memory in older adults. To further investigate the association between T. gondii seropositivity and memory in nondemented older adults, we obtained serum samples from 114 non-demented older adults evaluated by the Alzheimer’s Disease and Research Center at Washington University in St. Louis Missouri, USA. We determined T. gondii seropositivity and anti-T. gondii IgG antibody titer and examined associations with memory function while controlling for socioeconomic status, education level, age, and apolipoprotein E4 status. There were few associations between T. gondii seropositivity or anti-T. gondii IgG antibodies and memory, although there …

Acute Physiologic Stress And Subsequent Anxiety Among Family Members Of Icu Patients, Sarah J. Beesley, Ramona O. Hopkins, Julianne Holt-Lunstad, Emily L. Wilson, Jorie Butler, Kathryn G. Kuttler, James Orme, Samuel M. Brown, Eliotte L. Hirshberg

Faculty Publications

Objectives: The ICU is a complex and stressful environment and is associated with significant psychologic morbidity for patients and their families. We sought to determine whether salivary cortisol, a physiologic measure of acute stress, was associated with subsequent psychologic distress among family members of ICU patients.

Design: This is a prospective, observational study of family members of adult ICU patients.

Setting: Adult medical and surgical ICU in a tertiary care center.

Subjects: Family members of ICU patients. Interventions: Participants provided five salivary cortisol samples over 24 hours at the time of the patient ICU admission. The primary measure of cortisol …

Helicobacter Pylori Moderates The Association Between 5-Mthf Concentration And Cognitive Function In Older Adults, Bruce L. Brown, Andrew N. Berrett, Shawn D. Gale, Lance D. Erickson, Dawson W. Hedges

Faculty Publications

Objective: To explore potential interactions between folate-cycle factors and Helicobacter pylori seropositivity in the prediction of cognitive function. Methods We used data obtained from the 1999–2000 continuous National Health and Nutrition Examination Survey produced by the United States’ Centers for Disease Control and Prevention. Using Ordinary Least Squares regression, we tested for associations between multiple folate-cycle factors, Helicobacter pylori seropositivity, and cognitive function assessed by the digit symbol coding subtest of the Wechsler Adult Intelligence Scale-III. We then tested for interactions between each of the folate-cycle factors and Helicobacter pylori in the prediction of cognitive function.

Results: Although Helicobacter pylori …

Sleep Disturbances And Depression Severity In Patients With Parkinson’S Disease, Daniel Kay, Jared J. Tanner, Dawn Bowers

Faculty Publications

Objectives: Parkinson’s disease (PD) is a multisystem movement disorder associated with sleep disturbance and depression. Sleep disturbances and depression severity share a bidirectional association. This association may be greater in individuals who are more vulnerable to the deleterious consequences of sleep disturbance and depression severity. We investigated whether the association between sleep disturbances and depression severity is greater in patients with PD than in matched controls (MC).

Materials and Methods: The study sample (N = 98) included 50 patients with idiopathic PD and 48 age-, race-, sex-, and education-matched controls. Sleep disturbances were assessed using self-reported total sleep time (TST) …

Violent Video Games, Externalizing Behavior, And Prosocial Behavior: A Five-Year Longitudinal Study During Adolescence, Sarah M. Coyne, Wayne A. Warburton, Lee W. Essig, Laura A. Stockdale

Faculty Publications

Decades of research on the effects of media violence have examined associations between viewing aggressive material in the media and aggression and prosocial behavior. However, the existing longitudinal studies have tended to exclusively examine aggression and prosocial behavior as outcomes, with a limited range of potential mediators. The current study examines associations between playing violent video games and externalizing and prosocial behavior over a 5-year period across adolescence. Additionally, the study examines potential mediators of these associations, including empathic concern, benevolence, and self-regulation. Participants included 488 adolescents (MAge of child at Wave 1 􏰀13.83, SD 􏰀 0.98) and their parents, …

“Can’T Live With Or Without Them:” Transitions And Young Adults’ Perceptions Of Sibling Relationships, Alexander C. Jensen Phd, Shawn D. Whiteman, Karen L. Fingerman

Faculty Publications

Extant research documents how siblings’ relationships develop from childhood through adolescence; yet, we know little about how sibling relationships change in young adulthood. Rooted in life course theory, this 2-wave longitudinal study investigated changes in sibling closeness and conflict, and the roles of life transitions and sibling similarity in life stage. Participants included 273 young adults from 180 families who reported on 340 sibling relationships (Time 1 M age = 24.45, SD = 5.33; Time 2 M age = 30.23, SD = 5.33). Multilevel repeated measures analysis of covariance indicated that, on average, siblings’ perceptions of conflict declined over the …

Project Sweat (Summer Weight And Environmental Assessment Trial): Study Protocol Of An Observational Study Using A Multistate, Prospective Design That Examines The Weight Gain Trajectory Among A Racially And Ethnically Diverse Convenience Sample Of Economically Disadvantaged School-Age Children, Laura C. Hopkins, Christine Penicka, Carly Evich, Blake Jones, Carolyn Gunther

Faculty Publications

Introduction Racial/ethnic minority school-age children are at risk for unhealthy weight gain during the summer, and there is a dearth of information regarding the underlying behavioural and environmental factors. The study objective is to provide an in-depth examination of dietary and physical activity behaviours and food, physical activity, and social environments of African American and Hispanic school-age children during the summer.

Methods and analysis An observational study will be conducted using a multistate (Ohio and Indiana, USA) prospective design examining the weight gain trajectory among a racially/ethnically diverse convenience sample of economically disadvantaged school-age children. In addition, a subset of …

Strength Of Belief: Religious Commitment, Knowledge, And Hpvvaccination Adherence, Wendy C. Birmingham, Janelle L. B. Macintosh, Allison A. Vaughn, Tyler C. Graff

Faculty Publications

Objective:Human papillomavirus (HPV) infects millions of men and women annu-ally and is a substantial contributing factor in many cancers including oral, penile, anal,and cervical. Vaccination can reduce risk but adherence nationwide and, particularlyin highly religious states, is suboptimal. Religious principles of abstinence before mar-riage and total fidelity following marriage may create a belief of protection throughadherence to religious guidelines. However, while one partner may remain monoga-mous, one cannot be assured of their partner's behavior both before and after mar-riage. These misconceptions may create a barrier to religious youth's adherence tovaccine recommendations.Methods:We sampled single young adults, age 18 to 25 years, …

Female Family Members Lack Understanding Of Indeterminate Negative Brca1/2 Test Results Shared By Probands, Wendy C. Birmingham, Deborah O. Himes Msn, Aprn-Bc, Deborah K. Gibbons, Renea L. Beckstrand, Amanda Gammon, Anita Y. Kinney, Margaret F. Clayton

Faculty Publications

Genetic test results have important implications for close family members. Indeterminate negative results are the most common outcome of BRCA1/2 muta-tion testing. Little is known about family members' understanding of indeterminate negative BRCA1/2 test results. The purpose of this mixed-methods study was to in-vestigate how daughters and sisters received and understood genetic test results as shared by their mothers or sisters. Participants included 81 women aged 40–74 with mothers or sisters previously diagnosed with breast cancer and who received inde-terminate negative BRCA1/2 test results. Participants had never been diagnosed with breast cancer nor received their own genetic testing or counseling. …

Tolkien’S Phonoprint In Character Names Throughout His Invented Languages, Bruce L. Brown, Brad Wilcox, Wendy Baker-Smemoe, Timothy G. Morrison

Faculty Publications

J. R. R. Tolkien claimed to create names based on sound symbolism and invented languages. Previous studies revealed that Tolkien had his own phonoprint (tendency to use the same phonemes repeatedly for character names) regardless of his claims that they reflected different language origins. However, this research examined phonemes and syllables rather than names as whole units. This study compared 183 names from Tolkien’s works and 100 names from the nineteenth Century Us Census. The name recognition software linked names with known languages or provided a “generic” category when no match was found. Results showed no significant differences between the …

Sanctifcation And Cheating Among Emerging Adults, Scott Braithwaite, Paige Mcallister, Elena Henderson, Meghan Maddock, Krista Dowdle, Frank D. Fincham

Faculty Publications

Cheating—a general term for extradyadic romantic or sexual behavior that violates expectations in a committed romantic relationship—is common and leads to a number of poor outcomes. Religion has historically infuenced conceptions of romantic relationships, but societal attitudes about religion are in fux as many seek to retain spirituality even as afliations with formal religion decrease. The present study evaluated a potential predictor of cheating that is more spiritual than formally religious, the “psychospiritual” concept of relationship sanctifcation (i.e., the idea that one’s relationship itself is sacred). In a sample of college students in committed relationships (N=716), we found that higher …