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Full-Text Articles in Psychology
Does The Apoe-Ε4 Allele Differentially Influence Cognition: A Longitudinal Investigation In Healthy Older Adults At Risk For Alzheimer’S Disease, Aditya Kulkarni
Does The Apoe-Ε4 Allele Differentially Influence Cognition: A Longitudinal Investigation In Healthy Older Adults At Risk For Alzheimer’S Disease, Aditya Kulkarni
Dissertations, Theses, and Capstone Projects
Background: The apolipoprotein E (APOE) ε4 allele is the strongest susceptibility factor for sporadic, late-onset, Alzheimer’s disease (AD). However, not all persons who carry the ε4 allele show significant cognitive decline, and thus do not progress to dementia. The impact of the ε4 allele on memory decline has been documented primarily in populations already demonstrating cognitive impairment (i.e., those with mild cognitive impairment or dementia), with fewer investigations completed in baseline healthy older adults. Investigations of the ε4 allele and its influence on non-memory domains are also sparse in the literature. Furthermore, these cognitive investigations are typically cross-sectional and …