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University of Missouri, St. Louis
Addiction; CPP; drug-seeking; hormones; estrogen; progesterone; reinstatement; amphetamine
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Full-Text Articles in Psychology
Female Hormonal Influences On Stress- And Drug-Induced Reinstatement Of Extinguished Amphetamine-Induced Conditioned Place Preference, Melissa Elaine Bleile
Female Hormonal Influences On Stress- And Drug-Induced Reinstatement Of Extinguished Amphetamine-Induced Conditioned Place Preference, Melissa Elaine Bleile
Dissertations
One Animal paradigm used to study addiction is conditioned place preference. CPP is achieved when an animal develops a preference for environmental stimuli previously paired with subjective effects of a rewarding drug. Women may experience greater drug sensitivity than men, most likely due to estrogen levels. The purpose of this experiment was to assess the effects of female sex hormones on drug sensitivity and their interaction with the primary factors causing relapse, stress or drug re-exposure. Female rats were ovariectomized and received replacement hormones to control circulating hormone levels. These groups of animals were tested for amphetamine (AMPH)-induced CPP and …