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College of Science and Health Theses and Dissertations

Chronic fatigue syndrome

2017

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Full-Text Articles in Psychology

Investigating Post-Exertional Malaise As A Core Symptom Of Myalgic Encephalomyelitis And Chronic Fatigue Syndrome: A Meta-Analytic Approach, Abigail A. Brown Aug 2017

Investigating Post-Exertional Malaise As A Core Symptom Of Myalgic Encephalomyelitis And Chronic Fatigue Syndrome: A Meta-Analytic Approach, Abigail A. Brown

College of Science and Health Theses and Dissertations

Efforts to establish a reliable and valid case definition for myalgic encephalomyelitis and chronic fatigue syndrome (ME and CFS) have been complicated by an over-reliance on clinical consensus, and inconsistent application of established case definitions by researchers across study sites. This has resulted in the absence of an empirically-based case definition for ME and CFS, as well as failed replication studies on potential diagnostic tests and biomarkers. One step toward an empirically-driven case definition is determining which symptoms best discriminate between patients with ME and CFS versus controls. Post-exertional malaise (PEM) is considered a cardinal symptom of ME and CFS …