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Virginia Commonwealth University

Theses/Dissertations

Dementia

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Full-Text Articles in Psychology

The Influence Of Dementia Caregiver Mental Health On Quality Of Care In Argentina, Alejandra Morlett Paredes Jan 2014

The Influence Of Dementia Caregiver Mental Health On Quality Of Care In Argentina, Alejandra Morlett Paredes

Theses and Dissertations

This study examined the connections between cognitive functioning in individuals with dementia and caregiver burden, burden and mental health, mental health and quality of care. One hundred two dementia caregivers from San Lucas, Argentina completed questionnaires assessing these constructs. Caregiver burden, depression, anxiety, and satisfaction with life explained 18.8% of the variance in quality of care – respect and 14.7% of the variance in quality of care – provide. An SEM with generally adequate fit indices uncovered that cognitive functioning in individuals with dementia was inversely associated with caregiver burden, caregiver burden was inversely associated with mental health, and mental …


The Discriminative Stimulus Properties Of The Atypical Antipsychotic Clozapine In C57bl/6 Mice, Scott D. Philibin Jan 2006

The Discriminative Stimulus Properties Of The Atypical Antipsychotic Clozapine In C57bl/6 Mice, Scott D. Philibin

Theses and Dissertations

Serotonin and α1 adrenergic receptor antagonism may contribute to atypical antipsychotic drug effects. Clozapine (2.5 mg/kg) drug discrimination in C57BL/6 mice may selectively screen atypical antipsychotic drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol fully substitutes for clozapine. The present study demonstrated that the atypical antipsychotics quetiapine, sertindole, zotepine, iloperidone, melperone fully substituted for clozapine but aripiprazole did not. The typical antipsychotics fluphenazine and perphenazine failed to fully substitute for clozapine but chlorpromazine and thioridazine fully substituted for clozapine. This model does not differentiate between atypical and typical antipsychotic drugs but …