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Lifetime Estrogen Exposure And Brain-Derived Neurotrophic Factor: Implications For Cognitive Decline In Late Life, Joshua M. Matyi
Lifetime Estrogen Exposure And Brain-Derived Neurotrophic Factor: Implications For Cognitive Decline In Late Life, Joshua M. Matyi
All Graduate Theses and Dissertations, Spring 1920 to Summer 2023
The Cache County Study on Memory in Aging (CCSMA) is a longitudinal population-based study which took place in Cache County, Utah. The study followed 5092 older-adult residents (aged 65+) for approximately 12 years to examine risk and protective factors for dementia. Participants completed dementia screening and follow-up assessments across four triennial visits. Additionally, researchers gathered information regarding demographics, reproductive history (e.g. age of menopause; hormone replacement therapy [HRT]) and other health-related factors, such as physical activity. Genotyping of DNA was completed for a genetic variation of genes for brain-derived neurotrophic factor (BDNF), a protein found in the brain associated with …