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Full-Text Articles in Psychology
The Role Of Bdnf In 17Β-Estradiol-Induced Facilitation Of Extinction Of Cocaine Seeking, Hanna Yousuf
The Role Of Bdnf In 17Β-Estradiol-Induced Facilitation Of Extinction Of Cocaine Seeking, Hanna Yousuf
Theses and Dissertations
Females are more susceptible to drug dependence than males, and these differences in addictive behaviors are mediated, in large part, by 17β-estradiol (E2). E2 enhances memory in a variety of behavioral paradigms and may act to enhance the formation of drug-related memories. Interestingly, due to its mnemonic effects, E2 promotes drug seeking, but also may aid in extinguishing drug seeking behaviors. Treatment of addiction is modeled through extinction, and the infralimbic medial prefrontal cortex (IL-mPFC) is responsible for inhibiting drug seeking after extinction. However, the cellular mechanisms by which E2 facilitates extinction remain unknown. Previous work suggests that the memory-enhancing …
Memory Retrieval Is Maintained By Intrinsic And Synaptic Plasticity In Prelimbic Cortex, James Otis
Memory Retrieval Is Maintained By Intrinsic And Synaptic Plasticity In Prelimbic Cortex, James Otis
Theses and Dissertations
Abnormally strong memories underlie common disorders including addiction and post-traumatic stress disorder (PTSD). Memory disruption would therefore be beneficial for treatment of these disorders. Evidence reveals that cocaine conditioned place preference (CPP) memories are susceptible to long-lasting disruption during memory retrieval. For example, inhibition of β-adrenergic receptor (β-AR) activity within the prelimbic medial prefrontal cortex (PL-mPFC) prevents cocaine CPP memory retrieval, and this retrieval impairment is both long-lasting and prevents subsequent reinstatement of the CPP. Despite this, whether PL-mPFC β-AR activity is a fundamental mechanism required to maintain retrieval of other memories is unclear. Furthermore, how PL-mPFC β-AR activity maintains …
Dissociation Of Β1 And Β2 Adrenergic Receptor Subtypes In Retrieval And Reconsolidation Of A Cocaine Conditioned Place Preference, Michael Fitzgerald
Dissociation Of Β1 And Β2 Adrenergic Receptor Subtypes In Retrieval And Reconsolidation Of A Cocaine Conditioned Place Preference, Michael Fitzgerald
Theses and Dissertations
Drug-seeking behavior is maintained by encounters with drug-associated cues, and disrupting retrieval or reconsolidation of the drug-cue associations could reduce the risk of relapse. Previous work has shown beta-adrenergic receptor (beta-AR) antagonists can prevent retrieval or reconsolidation of a cocaine conditioned place preference (CPP) when administered either before or after test, respectively (Otis and Mueller, 2011; Otis et al., 2013). However, the specific beta-AR subtypes that mediate retrieval and reconsolidation of a cocaine CPP remain unknown. Here we used selective blockade of & beta-1 or beta-2-AR subtypes to determine the effects on retrieval and reconsolidation of a cocaine CPP. During …