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Neural Substrates Of Impaired Sensorimotor Timing In Adult Attention-Deficit/Hyperactivity Disorder, Eve M. Valera Phd, Rebecca M. C. Spencer, Thomas A. Zeffero Md, Phd, Nikos Makris Md, Phd, Thomas J. Spencer Md, Stephen V. Faraone Phd, Joseph Biederman Md, Larry J. Seidman Phd
Neural Substrates Of Impaired Sensorimotor Timing In Adult Attention-Deficit/Hyperactivity Disorder, Eve M. Valera Phd, Rebecca M. C. Spencer, Thomas A. Zeffero Md, Phd, Nikos Makris Md, Phd, Thomas J. Spencer Md, Stephen V. Faraone Phd, Joseph Biederman Md, Larry J. Seidman Phd
Rebecca M. C. Spencer
Background—Timing abilities are critical to the successful management of everyday activities and personal safety, and timing abnormalities have been argued to be fundamental to impulsiveness, a core symptom of attention-deficit/hyperactivity disorder (ADHD). Despite substantial evidence of timing deficits in ADHD youth, only two studies have explicitly examined timing in ADHD adults, and only at the supra-second time-scale. Also, the neural substrates of these deficits are largely unknown for both youth and adults with ADHD. The present study examined sub-second sensorimotor timing and its neural substrates in ADHD adults. Methods—Using fMRI, we examined paced and unpaced finger tapping in a sample …