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Adolescent Binge Drinking Leads To Changes In Alcohol Drinking, Anxiety, And Amygdalar Corticotropin Releasing Factor Cells In Adulthood In Male Rats, Heather Richardson, N. W. Gilpin, C. A. Karanikas
Adolescent Binge Drinking Leads To Changes In Alcohol Drinking, Anxiety, And Amygdalar Corticotropin Releasing Factor Cells In Adulthood In Male Rats, Heather Richardson, N. W. Gilpin, C. A. Karanikas
Heather Richardson
Heavy episodic drinking early in adolescence is associated with increased risk of addiction and other stress-related disorders later in life. This suggests that adolescent alcohol abuse is an early marker of innate vulnerability and/or binge exposure impacts the developing brain to increase vulnerability to these disorders in adulthood. Animal models are ideal for clarifying the relationship between adolescent and adult alcohol abuse, but we show that methods of involuntary alcohol exposure are not effective. We describe an operant model that uses multiple bouts of intermittent access to sweetened alcohol to elicit voluntary binge alcohol drinking early in adolescence (~postnatal days …
Genetical Genomic Determinants Of Alcohol Consumption In Rats And Humans, Heather Richardson, Boris Tabakoff, Laura Saba, Morton Printz, Pam Flodman, Colin Hodgkinson, David Goldman, George Koob, Katerina Kechris, Richard L. Bell, Norbert Hubner, Matthias Heinig, Michal Pravenec, Jonathan Mangion, Lucie Legault, Maurice Dongier, Katherine M. Conigrave, John B. Whitfield, John Saunders, Bridget Grant, Paula L. Hoffman
Genetical Genomic Determinants Of Alcohol Consumption In Rats And Humans, Heather Richardson, Boris Tabakoff, Laura Saba, Morton Printz, Pam Flodman, Colin Hodgkinson, David Goldman, George Koob, Katerina Kechris, Richard L. Bell, Norbert Hubner, Matthias Heinig, Michal Pravenec, Jonathan Mangion, Lucie Legault, Maurice Dongier, Katherine M. Conigrave, John B. Whitfield, John Saunders, Bridget Grant, Paula L. Hoffman
Heather Richardson
Background: We have used a genetical genomic approach, in conjunction with phenotypic analysis of alcohol consumption, to identify candidate genes that predispose to varying levels of alcohol intake by HXB/BXH recombinant inbred rat strains. In addition, in two populations of humans, we assessed genetic polymorphisms associated with alcohol consumption using a custom genotyping array for 1,350 single nucleotide polymorphisms (SNPs). Our goal was to ascertain whether our approach, which relies on statistical and informatics techniques, and non-human animal models of alcohol drinking behavior, could inform interpretation of genetic association studies with human populations. Results: In the HXB/BXH recombinant inbred (RI) …