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Deletion Of Bax Eliminates Sex Differences In The Mouse Forebrain, Geert De Vries, N. G. Forger, G. J. Rosen, E. M. Waters, D. Jacobs, R. B. Simerly
Deletion Of Bax Eliminates Sex Differences In The Mouse Forebrain, Geert De Vries, N. G. Forger, G. J. Rosen, E. M. Waters, D. Jacobs, R. B. Simerly
Geert De Vries
Several of the best-studied sex differences in the mammalian brain are ascribed to the hormonal control of cell death. This conclusion is based primarily on correlations between pyknotic cell counts in development and counts of mature neurons in adulthood; the molecular mechanisms of hormone-regulated, sexually dimorphic cell death are unknown. We asked whether Bax, a member of the Bcl-2 family of proteins that is required for cell death in many developing neurons, might be essential for sex differences in neuron number. We compared Bax knockout mice and their WT siblings, focusing on two regions of the mouse forebrain that show …
Sex Differences In Adult And Developing Brains; Compensation, Compensation, Compensation, Geert De Vries
Sex Differences In Adult And Developing Brains; Compensation, Compensation, Compensation, Geert De Vries
Geert De Vries
Despite decades of research, we do not know the functional significance of most sex differences in the brain. We are heavily invested in the idea that sex differences in brain structure cause sex differences in behavior. We rarely consider the possibility that sex differences in brain structure may also prevent sex differences in overt functions and behavior, by compensating for sex differences in physiological conditions, e.g. gonadal hormone levels that may generate undesirable sex differences if left unchecked. Such a dual function for sex differences is unlikely to be restricted to adult brains. This review will entertain the possibility that …