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Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Smith, Kristy Nielson, John Woodard, Michael Seidenberg, Matthew Verber, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa Lancaster, Stephen Rao
Does Physical Activity Influence Semantic Memory Activation In Amnestic Mild Cognitive Impairment?, J. Smith, Kristy Nielson, John Woodard, Michael Seidenberg, Matthew Verber, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa Lancaster, Stephen Rao
Kristy Nielson
The effect of physical activity (PA) on functional brain activation for semantic memory in amnestic mild cognitive impairment (aMCI) was examined using event-related functional magnetic resonance imaging during fame discrimination. Significantly greater semantic memory activation occurred in the left caudate of High- versus Low-PA patients, (P=0.03), suggesting PA may enhance memory-related caudate activation in aMCI.
Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao
Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao
Kristy Nielson
Leisure-time physical activity (PA) and exercise training are known to help maintain cognitive function in healthy older adults. However, relatively little is known about the effects of PA on cognitive function or brain function in those at increased risk for Alzheimer’s disease through the presence of the apolipoproteinE epsilon4 (APOE-ε4) allele, diagnosis of mild cognitive impairment (MCI), or the presence of metabolic disease. Here, we examine the question of whether PA and exercise interventions may differentially impact cognitive trajectory, clinical outcomes, and brain structure and function among individuals at the greatest risk for AD. The literature suggests that the protective …
Interactive Effects Of Physical Activity And Apoe-Ε4 On Bold Semantic Memory Activation In Healthy Elders, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Interactive Effects Of Physical Activity And Apoe-Ε4 On Bold Semantic Memory Activation In Healthy Elders, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Sally Durgerian, Piero Antuono, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Kristy Nielson
Evidence suggests that physical activity (PA) is associated with the maintenance of cognitive function across the lifespan. In contrast, the apolipoproteinE-ε4 (APOE-ε4) allele, a genetic risk factor for Alzheimer's disease (AD), is associated with impaired cognitive function. The objective of this study was to examine the interactive effects of PA and APOE-ε4 on brain activation during memory processing in older (ages 65–85) cognitively intact adults. A cross-sectional design was used with four groups (n = 17 each): (1) Low Risk/Low PA; (2) Low Risk/High PA; (3) High Risk/Low PA; and (4) High Risk/High PA. PA level was based on …
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Kristy Nielson
Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …