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Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao
Lifestyle And Genetic Contributions To Cognitive Decline And Hippocampal Structure And Function In Healthy Aging, John L. Woodard, Michael Sugarman, Kristy A. Nielson, J. Carson Smith, Michael Seidenberg, Sally Durgerian, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Monica A. Matthews, Stephen M. Rao
Kristy Nielson
Background: Engagement in cognitively stimulating activities (CA) and leisure time physical activity (PA) have been associated with maintaining cognitive performance and reducing the likelihood of cognitive decline in older adults. However, neural mechanisms underlying protective effects of these lifestyle behaviors are largely unknown. In the current study, we investigated the effect of self-reported PA and CA on hippocampal volume and semantic processing activation during a fame discrimination task, as measured by functional magnetic resonance imaging (fMRI). We also examined whether possession of the apolipoprotein E (APOE) ?4 allele could moderate the effect of PA or CA on hippocampal structure or …
Prediction Of Cognitive Decline In Healthy Older Adults Using Fmri, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, J Carson Smith, Piero Antuono, Sally Durgerian, Leslie Guidotti, Qi Zhang, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Prediction Of Cognitive Decline In Healthy Older Adults Using Fmri, John L. Woodard, Michael Seidenberg, Kristy A. Nielson, J Carson Smith, Piero Antuono, Sally Durgerian, Leslie Guidotti, Qi Zhang, Alissa Butts, Nathan Hantke, Melissa A. Lancaster, Stephen M. Rao
Kristy Nielson
Few studies have examined the extent to which structural and functional MRI, alone and in combination with genetic biomarkers, can predict future cognitive decline in asymptomatic elders. This prospective study evaluated individual and combined contributions of demographic information, genetic risk, hippocampal volume, and fMRI activation for predicting cognitive decline after an 18-month retest interval. Standardized neuropsychological testing, an fMRI semantic memory task (famous name discrimination), and structural MRI (sMRI) were performed on 78 healthy elders (73% female; mean age = 73 years, range = 65 to 88 years). Positive family history of dementia and presence of one or both apolipoprotein …