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Full-Text Articles in Psychology
Temporally Graded Activation Of Neocortical Regions In Response To Memories Of Different Ages, J Woodard, M Seidenberg, Kristy Nielson, S Miller, M Franczak, P Antuono, K Douville, S Rao
Temporally Graded Activation Of Neocortical Regions In Response To Memories Of Different Ages, J Woodard, M Seidenberg, Kristy Nielson, S Miller, M Franczak, P Antuono, K Douville, S Rao
Kristy Nielson
The temporally graded memory impairment seen in many neurobehavioral disorders implies different neuroanatomical pathways and/or cognitive mechanisms involved in storage and retrieval of memories of different ages. A dynamic interaction between medial-temporal and neocortical brain regions has been proposed to account for memory’s greater permanence with time. Despite considerable debate concerning its time-dependent role in memory retrieval, medial-temporal lobe activity has been well studied. However, the relative participation of neocortical regions in recent and remote memory retrieval has received much less attention. Using functional magnetic resonance imaging, we demonstrate robust, temporally graded signal differences in posterior cingulate, right middle frontal, …
An Evaluation Of Distinct Volumetric And Functional Mri Contributions Toward Understanding Age And Task Performance: A Study In The Basal Ganglia, S Langenecker, E Briceno, N Hamid, Kristy Nielson
An Evaluation Of Distinct Volumetric And Functional Mri Contributions Toward Understanding Age And Task Performance: A Study In The Basal Ganglia, S Langenecker, E Briceno, N Hamid, Kristy Nielson
Kristy Nielson
Prior work by our group and others has implicated the basal ganglia as important in age-related differences in tasks involving motor response control. The present study used structural and functional MRI approaches to analyze this region of interest (ROI) toward better understanding the contributions of structural and functional MRI measures to understanding age-related and task performance-related cognitive differences. Eleven healthy elders were compared with 11 healthy younger adults while they completed the “go” portion of a complex Go/No-go task. Separate ROI's in the bilateral caudate (C) and putamen/globus pallidus (PGp) were studied based upon previous findings of age-related functional MRI …