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Donepezil’S Effect On Cardiac Function In Patients With Alzheimer’S Disease Through An In Vivo, Non Invasive Measure Of Cardiac Autonomic Function, Lewis P. Hackett
Donepezil’S Effect On Cardiac Function In Patients With Alzheimer’S Disease Through An In Vivo, Non Invasive Measure Of Cardiac Autonomic Function, Lewis P. Hackett
Psychology Theses & Dissertations
The aim of the current study was to explore the effects of the medication Donepezil (Aricept®) on cardiac autonomic function for individuals diagnosed with mild to moderate (probable) Alzheimer’s disease (AD). Using age (± 3 years) and gender matched controls, differences in heart rate variability (HRV) among individuals with Alzheimer’s disease were compared to healthy controls over a period of six months (session 1 [baseline], session 2 [3 months], and session 3 [6 months]) in both supine and standing positions. HRV was obtained through frequency-domain (Low Frequency Power, High Frequency Power, RMSSD, LF/HF Ratio) and time-domain (six minutes) measures using …