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Group Ii Metabolic Glutamate Receptors In The Basal Amygdala Regulate Sleep And Fear-Induced Alterations In Sleep, Enheng Dong
Group Ii Metabolic Glutamate Receptors In The Basal Amygdala Regulate Sleep And Fear-Induced Alterations In Sleep, Enheng Dong
Theses and Dissertations in Biomedical Sciences
Glutamate is a major excitatory neurotransmitter in the brain and it has been recognized as playing an essential role in activating and maintaining arousal. Group II metabotropic glutamate (mGlu II) receptors are expressed in the amygdala, a brain structure important in the regulation of stress and anxiety as well as in the regulation of sleep and arousal. Our lab has found that the central nucleus of the amygdala (CNA) is involved in the emotional modulation of sleep. The basal amygdala (BA), which has direct connections with the CNA, is involved in conditioned fear and fear extinction. However, the potential role …