Psychology Commons^™

An Ewas Of Dementia Biomarkers And Their Associations With Age, African Ancestry, And Ptsd, Mark W. Miller, Erika J. Wolf, Xiang Zhao, Mark W. Logue, Sage E. Hawn

Psychology Faculty Publications

Background

Large-scale cohort and epidemiological studies suggest that PTSD confers risk for dementia in later life but the biological mechanisms underlying this association remain unknown. This study examined this question by assessing the influences of PTSD, APOE ε4 genotypes, DNA methylation, and other variables on the age- and dementia-associated biomarkers Aβ40, Aβ42, GFAP, NfL, and pTau-181 measured in plasma. Our primary hypothesis was that PTSD would be associated with elevated levels of these markers.

Methods

Analyses were based on data from a PTSD-enriched cohort of 849 individuals. We began by performing factor analyses of the biomarkers, the results of which …

Successfully Aging At Work Or Successfully Working While Aging? The Importance Of Older Workers' Psychological Well-Being, William P. Jimenez

Psychology Faculty Publications

Frank, 62, has been working at the same company for the past 32 years. His strong work ethic, subject-matter expertise, and continued excellent performance have saved him from several waves of layoffs and restructuring. Over the years Frank has become cynical. Gradually, many of Frank’s close colleagues were let go, and he has had difficulty connecting with newer employees. Although he is not particularly happy at his job, Frank is determined to continue working for his employer until at least 66, which is when he can start collecting Social Security benefits without penalty.