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Full-Text Articles in Psychology
Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao
Physical Activity And Brain Function In Older Adults At Increased Risk For Alzheimer’S Disease, J. Carson Smith, Kristy A. Nielson, John L. Woodard, Michael Seidenberg, Stephen M. Rao
Psychology Faculty Research and Publications
Leisure-time physical activity (PA) and exercise training are known to help maintain cognitive function in healthy older adults. However, relatively little is known about the effects of PA on cognitive function or brain function in those at increased risk for Alzheimer’s disease through the presence of the apolipoproteinE epsilon4 (APOE-ε4) allele, diagnosis of mild cognitive impairment (MCI), or the presence of metabolic disease. Here, we examine the question of whether PA and exercise interventions may differentially impact cognitive trajectory, clinical outcomes, and brain structure and function among individuals at the greatest risk for AD. The literature suggests that the protective …
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Semantic Memory Functional Mri And Cognitive Function After Exercise Intervention In Mild Cognitive Impairment, J Carson Smith, Kristy A. Nielson, Piero Antuono, Jeri-Annette Lyons, Ryan J. Hanson, Alissa Butts, Nathan Hantke, Matthew D. Verber
Psychology Faculty Research and Publications
Mild cognitive impairment (MCI) is associated with early memory loss, Alzheimer's disease (AD) neuropathology, inefficient or ineffective neural processing, and increased risk for AD. Unfortunately, treatments aimed at improving clinical symptoms or markers of brain function generally have been of limited value. Physical exercise is often recommended for people diagnosed with MCI, primarily because of its widely reported cognitive benefits in healthy older adults. However, it is unknown if exercise actually benefits brain function during memory retrieval in MCI. Here, we examined the effects of exercise training on semantic memory activation during functional magnetic resonance imaging (fMRI). Seventeen MCI participants …