Psychology Commons^™

The Progression Of Β-Amyloid Deposition In The Frontal Cortex Of The Aged Canine, Takao Satou, Brian J. Cummings, Elizabeth Head, Kristy A. Nielson, Fletcher F. Hahn, Norton W. Milgram, Peter Velazquez, David H. Cribbs, Andrea J. Tenner, Carl W. Cotman

Psychology Faculty Research and Publications

Brains from 41 aged canines (≥10 years of age) were examined immunohistochemically to characterize the laminar distribution and age-related progression of β-amyloid (Aβ) in frontal cortex. We classified the Aβ patterns into four distinct types. Type I was characterized by small, faint deposits of Aβ in deep cortical layers. Type II consisted of diffuse deposits of Aβ mainly in layers V and VI. Type III had both dense plaques in superficial layers, and diffuse deposits in deep layers. Finally, Type IV had solely dense plaques throughout all layers of cortex. We compared the A …