Psychology Commons^™

Freesurfer Vs. Manual Tracing: Detecting Future Cognitive Decline In Healthy Older Adults At-Risk For Alzheimer's Disease, Alissa Butts

Dissertations (1934 -)

Alzheimer's disease (AD) is a neurodegenerative pathological process that is thought to begin years prior to observable symptom onset. The hippocampus appears to be particularly vulnerable to the underlying brain pathology of AD. Hippocampal volume is a sensitive measure in predicting conversion from mild cognitive impairment to AD, but less is known regarding the use of hippocampal volume in asymptomatic individuals at risk for AD who eventually decline. The inconsistent findings may, in part, be due to the chosen method of hippocampal segmentation. FreeSurfer (FS) and manual tracings (MT) are two common segmentation techniques that have unique costs and benefits. …