Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Psychology
Neural Circuitry Engaged During Unsuccessful Motor Inhibition In Pediatric Bipolar Disorder, Ellen Leibenluft, Brendan A. Rich, Deborah T. Vinton, Eric E. Nelson, Stephen J. Fromm, Lisa H. Berghorst, Paramijit Joshi, Adelaide Robb, Russell J. Schachar, Daniel P. Dickstein, Erin Tone, Daniel S. Pine
Neural Circuitry Engaged During Unsuccessful Motor Inhibition In Pediatric Bipolar Disorder, Ellen Leibenluft, Brendan A. Rich, Deborah T. Vinton, Eric E. Nelson, Stephen J. Fromm, Lisa H. Berghorst, Paramijit Joshi, Adelaide Robb, Russell J. Schachar, Daniel P. Dickstein, Erin Tone, Daniel S. Pine
Psychology Faculty Publications
Objective: Deficits in motor inhibition may contribute to impulsivity and irritability in children with bipolar disorder (BPD). Therefore, studies of the neural circuitry engaged during failed motor inhibition in pediatric BPD may contribute to our understanding of the pathophysiology of the illness. We tested the hypothesis that children with BPD and controls would differ in ventral prefrontal cortex (vPFC), striatal, and anterior cingulate activation during unsuccessful motor inhibition. We also compared activation in medicated vs. unmedicated children with BPD, and in children with BPD and ADHD (BPD+ADHD) vs. those with BPD but without ADHD (BPD-ADHD).
Method: Event-related fMRI study comparing …