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The Effect Of Olanzapine On Craving And Alcohol Consumption, Kent E. Hutchinson, Lara Ray, Erica Sandman, Marie-Christine Rutter Goodworth, Annie Peters, Dena Davidson, Robert Swift
The Effect Of Olanzapine On Craving And Alcohol Consumption, Kent E. Hutchinson, Lara Ray, Erica Sandman, Marie-Christine Rutter Goodworth, Annie Peters, Dena Davidson, Robert Swift
Faculty Publications - Doctor of Psychology (PsyD) Program
Previous studies have indicated that olanzapine decreases craving after a priming dose of alcohol, that craving after a priming dose of alcohol is greater among individuals with the seven-repeat allele of the DRD4 variable number of tandem repeats (VNTR) polymorphism, and that the effect of olanzapine (a D2/D4 antagonist) is more pronounced among individuals with this allele. The present study tested the hypothesis that olanzapine may be differentially effective at reducing cue-elicited craving and differentially effective as a treatment for alcohol dependence over the course of a 12-week, randomized, placebo-controlled trial among individuals with and without the seven-repeat allele. Participants …