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Olanzapine Attenuates Cue-Elicited Craving For Tobacco, Kent E. Hutchinson, Marie-Christine Rutter Goodworth, Raymond Niaura, Robert Swift, Wallace B. Pickworth, Laura Sobik
Olanzapine Attenuates Cue-Elicited Craving For Tobacco, Kent E. Hutchinson, Marie-Christine Rutter Goodworth, Raymond Niaura, Robert Swift, Wallace B. Pickworth, Laura Sobik
Faculty Publications - Doctor of Psychology (PsyD) Program
Rationale: Recent biological conceptualizations of craving and addiction have implicated mesolimbic dopamine activity as a central feature of the process of addiction. Imaging, and pharmacological studies have supported a role for dopaminergic structures in cue-elicited craving for tobacco.
Objective: If mesolimbic dopamine activity is associated with cue-elicited craving for tobacco, a dopamine antagonist should attenuate cueelicited craving for tobacco. Thus, the aim of the present study was to determine whether an atypical antipsychotic (olanzapine, 5 mg) decreased cue-elicited craving for tobacco.
Method: Participants were randomly assigned to 5 days of pretreatment with olanzapine (5 mg; n=31) or were randomly assigned …