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Psychedelic-Assisted Therapy: Support For The Rebus Hypothesis And Its Application To Specific Psychiatric Illnesses, Wren Cilimburg
Psychedelic-Assisted Therapy: Support For The Rebus Hypothesis And Its Application To Specific Psychiatric Illnesses, Wren Cilimburg
CMC Senior Theses
For centuries, psychedelic substances have been a part of human culture. Classic psychedelics such as LSD and psilocybin are characterized by their agonism of 5HT-2A receptors, and recent clinical trials have found that these substances hold great promise for treating mental disorders. Neurobiological evidence supports the recent theory that psychedelic-assisted therapy works by increasing neuroplasticity and allowing for the revision of maladaptive predictions. This theory is called the REBUS hypothesis, and it is situated within a predictive processing model of cognition. There is evidence that individuals with mental disorders such as depression, addiction, and eating disorders have a diminished ability …