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Trustworthiness Appraisal Deficits In Borderline Personality Disorder Are Associated With Prefrontal Cortex, Not Amygdala, Impairment, Eric A. Fertuck, Jack Grinband, J. John Mann, Joy Hirsch, Kevin Ochsner, Paul Pilkonis, Jeff Erbe, Barbara Stanley
Trustworthiness Appraisal Deficits In Borderline Personality Disorder Are Associated With Prefrontal Cortex, Not Amygdala, Impairment, Eric A. Fertuck, Jack Grinband, J. John Mann, Joy Hirsch, Kevin Ochsner, Paul Pilkonis, Jeff Erbe, Barbara Stanley
Publications and Research
Background
Borderline Personality Disorder (BPD) is associated with sensitivity to signals of interpersonal threats and misplaced trust in others. The amygdala, an integral part of the threat evaluation and response network, responds to both fear- and trust-related stimuli in non-clinical samples, and is more sensitive to emotional stimuli in BPD compared to controls. However, it is unknown whether the amygdalar response can account for deficits of trust and elevated sensitivity to interpersonal threat in BPD.
Methods
Facial stimuli were presented to 16 medication-free women with BPD and 17 demographically-matched healthy controls (total n = 33). Participants appraised fearfulness or trustworthiness …