Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 4 of 4
Full-Text Articles in Psychology
Meth Causes Expression Of 8-Ohg In The Addiction Pathway And Leads To Increased S-Glutathionylation Of The Vesicular Monoamine Transportor Via The Sigma Receptor, Taylor Hyde, Scott Steffensen
Meth Causes Expression Of 8-Ohg In The Addiction Pathway And Leads To Increased S-Glutathionylation Of The Vesicular Monoamine Transportor Via The Sigma Receptor, Taylor Hyde, Scott Steffensen
Journal of Undergraduate Research
Methamphetamine (METH) is a highly addictive drug of abuse and which results in serious financial, societal, and individual consequences in the United States. In 2005, METH abuse costs the country billions dollars each year. Societal and individual costs as a result of METH use are also high. Knowing how METH acts in the brain is a significant step in developing a pharmocotherapeutic treatment for METH addiction.
Role Of Sigma Receptors In Low-Dose Methamphetamine Modulation Of Dopamine Release In The Nucleus Accumbens, Gilbert Marchant, Scott Steffensen
Role Of Sigma Receptors In Low-Dose Methamphetamine Modulation Of Dopamine Release In The Nucleus Accumbens, Gilbert Marchant, Scott Steffensen
Journal of Undergraduate Research
Methamphetamine (METH) is an addictive drug of abuse and METH use is a growing problem in the United States. The current dogma states that psychostimulants such as METH attack the mesocorticolimbic dopamine (DA) system, leading to abnormally high DA release when drugs of abuse are taken (Volkow et al., 2004). A key target area of the mesocorticolimbic system is the nucleus accumbens (NAc). Specifically, DA release in the NAc has been associated with reward and motivation (Oleson et al. 2012).
Identification Of Location And Timing Of Ros Production In Response To Meth Exposure, Andrew Lamprecht, Scott Steffensen
Identification Of Location And Timing Of Ros Production In Response To Meth Exposure, Andrew Lamprecht, Scott Steffensen
Journal of Undergraduate Research
Methamphetamine is an extremely addictive drug that acts on the pleasure center of the brain. It causes an increase in the release of dopamine (DA) into the synaptic cleft. This rapid release of DA causes the “rush” felt by drug users. It also causes severe malfunctions in the brain such as anxiety, mood disorders, increased violence, reduced motor skills, impaired verbal learning, and psychosis. Among other things, the cause for these harmful effects could be related to Reactive Oxygen Species (ROS) and their resulting oxidative damage. Oxidative damage has been suggested to constitute early signaling events in programmed cell death, …
Effect Of Methamphetamine On Basal And Phasic Dopamine Release In The Striatum, Krisana Finlay, Scott Steffensen
Effect Of Methamphetamine On Basal And Phasic Dopamine Release In The Striatum, Krisana Finlay, Scott Steffensen
Journal of Undergraduate Research
The purpose of this experiment was to determine the action mechanism of the psychostimulant methamphetamine (METH) on basal and phasic dopamine (DA) release in the nucleus accumbens. We investigated METH and its method of action. This was done to better understand the detailed mechanism behind METH and to provide better addiction-solving tools. Previous METH research provided a great starting point, showing a reduction in DA transmission and tyrosine hydroxylase, and increased DA axon and terminal damage, apoptosis (cell death) and axon degeneration.