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Change Over Time Of White Matter Hyperintensities And Cognitive Scores In The Cache County Memory And Aging Study, Zachary Mcdonnell, Dr. Erin Bigler
Change Over Time Of White Matter Hyperintensities And Cognitive Scores In The Cache County Memory And Aging Study, Zachary Mcdonnell, Dr. Erin Bigler
Journal of Undergraduate Research
The Cache County Study on Memory in Aging (CCMA) includes a sample of over 400 individuals with magnetic resonance imaging (MRI) (Bigler et al., 2000). Studies have shown that White Matter Hyperintensities (WMH) on MRIs are associated with not only cognitive decline, but degenerative disorders like Alzheimer’s disease (Philip Scheltens et al., 1998). A common and widely used clinical rating method for identifying WMH is the Scheltens Rating Scale (PH Scheltens et al., 1993). This scale rates WMH, Grey Matter Hyperintensities (GMH), Periventricular White Matter Hyperintensities (PWM), and Infratentorial Signal Hyperintensites (IFH) in a semi-quantitative scale that can be easily …