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The Effects Of Transdermal Nicotine On Tobacco/Nicotine Withdrawal And Concurrently Administered Cigarettes In Women And Men, Betha A. Kleykamp
The Effects Of Transdermal Nicotine On Tobacco/Nicotine Withdrawal And Concurrently Administered Cigarettes In Women And Men, Betha A. Kleykamp
Theses and Dissertations
Transdermal nicotine (TN) is a smoking cessation pharmacotherapy thought to work by suppressing tobacco/nicotine withdrawal and reducing the effect of a concurrently smoked tobacco cigarette. Clinical trials suggest that TN may be less efficacious for women. This study explored the possibility of gender differences in response to transdermal nicotine in 54 women and 70 men. Participants completed four within-subject, double-blind, randomized sessions corresponding to 0, 7, 14, and 21 mg TN and 4-hrs after TN application smoked an own-brand cigarette. Prior to session onset participants completed ≥ 8 hours of verified tobacco cigarette abstinence (i.e., expired air carbon monoxide levels …