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Unexpected Effects Of Perinatal Gonadal Hormone Manipulations On Sexual Differentiation Of The Extrahypothalamic Arginine-Vasopressin System In Prairie Voles, Geert De Vries, J. S. Lonstein, B. D. Rood
Unexpected Effects Of Perinatal Gonadal Hormone Manipulations On Sexual Differentiation Of The Extrahypothalamic Arginine-Vasopressin System In Prairie Voles, Geert De Vries, J. S. Lonstein, B. D. Rood
Geert De Vries
The sexually dimorphic extrahypothalamic arginine-vasopressin (AVP) projections from the bed nucleus of the stria terminalis to the lateral septum (LS) and lateral habenula (LHb) are denser in males than females and, in rats, require males' perinatal exposure to gonadal hormones but the absence of such exposure in females. We examined perinatal hormone effects on development of this sex difference in prairie voles (Microtus ochrogaster), which show atypical effects of hormones on sexual differentiation of some reproductive behaviors. Neonatal castration reduced the number of AVP mRNA-expressing cells in the bed nucleus of the stria terminalis and AVP immunoreactivity (ir) in the …