Psychology Commons^™

Clinical And Cortical Decline In The Aphasic Variant Of Alzheimer’S Disease, Derin J. Cobia, Emily Joy Rogalski, Jaiashre Sridhar, Adam Martersteck, Benjamin Rader, Anupa K. Arora, Angela J. Fought, Eileen H. Bigio, Sandra Weintraub, Marek-Marsel Mesulam, Alfred Rademaker

Faculty Publications

Introduction—Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation.

Methods—Longitudinal quantitation of atrophy and language over 12 months was completed for PPA patients with and without positive amyloid PET (PPAAβ+ and PPAAβ−), an imaging biomarker of underlying Alzheimer’s disease. Results—Over 12 months, both PPA groups showed significantly greater cortical atrophy rates in the left versus right hemisphere, with a more widespread pattern in PPAAβ+. The PPAAβ− group also showed greater decline in performance on most language tasks. There was no obligatory relationship between the logopenic PPA variant and amyloid status. Effect sizes from quantitative MRI data were …