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Full-Text Articles in Psychology
Does The Apoe-Ε4 Allele Differentially Influence Cognition: A Longitudinal Investigation In Healthy Older Adults At Risk For Alzheimer’S Disease, Aditya Kulkarni
Does The Apoe-Ε4 Allele Differentially Influence Cognition: A Longitudinal Investigation In Healthy Older Adults At Risk For Alzheimer’S Disease, Aditya Kulkarni
Dissertations, Theses, and Capstone Projects
Background: The apolipoprotein E (APOE) ε4 allele is the strongest susceptibility factor for sporadic, late-onset, Alzheimer’s disease (AD). However, not all persons who carry the ε4 allele show significant cognitive decline, and thus do not progress to dementia. The impact of the ε4 allele on memory decline has been documented primarily in populations already demonstrating cognitive impairment (i.e., those with mild cognitive impairment or dementia), with fewer investigations completed in baseline healthy older adults. Investigations of the ε4 allele and its influence on non-memory domains are also sparse in the literature. Furthermore, these cognitive investigations are typically cross-sectional and …
Serial Position Effect Profiles And Their Neuroanatomical Correlates: Predictors Of Conversion To Alzheimer's Disease, Isabelle K. Avildsen
Serial Position Effect Profiles And Their Neuroanatomical Correlates: Predictors Of Conversion To Alzheimer's Disease, Isabelle K. Avildsen
Dissertations, Theses, and Capstone Projects
The current study was designed to determine whether targeted, premorbid, neuropsychological measures of the serial position effect (SPE) can detect and explain risk for later development of Alzheimer’s disease (AD). The study tested the utility of SPE measures in healthy controls (HC) and individuals already diagnosed with mild cognitive impairment (MCI) or AD. Aim 1 was to determine whether these sensitive, valid neuropsychological measures can explain disease risk. SPE of list-learning are highly sensitive cognitive markers that capture important elements of both linguistic and amnestic mechanisms of encoding, learning, and retrieval. Using the Rey Auditory Verbal Learning Test (RAVLT), we …
The Impact Of Cannabis Use On Neuropsychological And Neural Biomarkers Of Treatment Response In Schizophrenia Spectrum Disorders, Melanie B. Thies
The Impact Of Cannabis Use On Neuropsychological And Neural Biomarkers Of Treatment Response In Schizophrenia Spectrum Disorders, Melanie B. Thies
Dissertations, Theses, and Capstone Projects
Cannabis use among patients with schizophrenia-spectrum disorders (SSD) is at significantly greater levels than in healthy populations but the impact of cannabis on neural mechanisms of clinical improvement is poorly understood. Cognitive functioning and neural connectivity are disrupted as a result of both SSD and cannabis use, and research indicates that neuropsychological capacity and connectivity of the striatum, a region involved in salience and reward processing, may be integral to effective antipsychotic drug (AP) treatment response. Despite this overlap, no previous research has investigated the effect of cannabis on the brain functions implicated in AP treatment response. The present study …
Underlying Contribution Of Executive Functioning To Cognition And Academic Achievement In Individuals With Dystrophinopathy, Robert Fee
Dissertations, Theses, and Capstone Projects
Dystrophinopathy is a genetic disorder that results in the lack of or abnormal expression of the protein dystrophin. It is a disorder that alters cell structure and function, impacts the developing brain and brain function, presents with multi-domain cognitive deficits, and influences both mood and behavior. Cognitive impairments appear to be more localized to specific areas of functioning rather than a global deficit; however, deficits have been identified across multiple cognitive domains including language and aspects of executive functioning. A careful examination of the cognitive phenotype and its association to mutations affecting CNS isoforms is necessary to clarify the neuropsychological …
Attention In Hiv, Kathleen Marie Van Dyk
Attention In Hiv, Kathleen Marie Van Dyk
Dissertations, Theses, and Capstone Projects
In contrast to the striking benefit of advances in antiretroviral therapy on longevity and health in the HIV+ population, mild cognitive disorders persist (Heaton, Clifford et al., 2010). Additional factors that may be related to cognitive decline and warrant consideration in this population are aging and physical health status. Among cognitive domains affected, attention and processing speed have emerged as particularly vulnerable to the effects of HIV. There are also age effects observed in these domains, and we proposed that reduced physical health can also impact cognition in these areas, comparably to pain. Sensitive measures of attention that vary attentional …
Characterization Of Somatosensory Processing In Relation To Schizotypal Traits In A Sample Of Nonclinical Young Adults, Maureen Patricia Daly
Characterization Of Somatosensory Processing In Relation To Schizotypal Traits In A Sample Of Nonclinical Young Adults, Maureen Patricia Daly
Dissertations, Theses, and Capstone Projects
A core feature of schizophrenia spectrum disorders (SSDs) is a basic sensory (e.g., visual, auditory) processing disruption, yet few studies have examined somatosensation. The current dissertation project examined somatosensory processes among individuals at varying degrees of psychometric risk for psychosis using tactile texture and spatial discrimination and letter recognition tasks. Differential patterns of associations of somatosensory abilities with schizotypal trait dimensions (positive, negative, disorganized), independent of anxiety and depressive symptoms, and the relative contributions of bottom-up (peripheral and morphologic features) versus top-down (error types) processing were examined. It was hypothesized that: 1) performance on somatosensory tasks would account for significant …
Cognitive And Emotional Abnormalities In People With Systemic Lupus Erythematosus, Philip Watson
Cognitive And Emotional Abnormalities In People With Systemic Lupus Erythematosus, Philip Watson
Dissertations, Theses, and Capstone Projects
Systemic lupus erythematosus (SLE) is a multi-system autoimmune disorder characterized by the production of autoantibodies (ABs). Approximately 30-50% of patients produce ABs directed against N-Methyl-D-aspartic acid receptors (NMDARs). Previous research with animals has identified these ABs as being associated with amygdala damage and a deficit in fear conditioning. People with SLE can have damage to the amygdala. This study aimed to determine if emotional processing deficits occur in people with SLE and to associate such deficits, if they exist, with anti-NMDAR AB presence, length of disease, cognition, and mood. Fifty-eight (11 AB+, 24 AB-, 23 healthy) women participated in tasks …