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Dissertations, Theses, and Capstone Projects
Aging; anxiety; cognition; depression; Interleukin-1; sex differences
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Full-Text Articles in Psychology
Sex-Dependent Role Of Interleukin-1 Signaling In Emotional And Cognitive Behaviors In Mice: Phenotyping Male And Female Il1-R1 Null Mutant Mice, Jennifer Anne Johnson
Sex-Dependent Role Of Interleukin-1 Signaling In Emotional And Cognitive Behaviors In Mice: Phenotyping Male And Female Il1-R1 Null Mutant Mice, Jennifer Anne Johnson
Dissertations, Theses, and Capstone Projects
IL1-R1 null mutant mice (IL1-R1 KO) have reduced signaling in the interleukin-1 (IL-1) pathway, making them a convenient model for testing the importance of IL-1 in either the development or maintenance of mouse behaviors. Prior research has revealed impaired cognitive and emotional processes in adult male IL1-R1 KO mice, including impaired spatial learning and memory and decreased anxiety with associated impairments in hippocampal cell proliferation and signal transmission. The current studies explored the neuroanatomy and behavioral phenotype of both male and female IL1-R1 KO mice. An array of behavioral tests was administered, including retesting at an older age for cognitive …