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Full-Text Articles in Psychology
Relationships Between Age And White Matter Integrity In Children With Phenylketonuria, Erika M. Wesonga
Relationships Between Age And White Matter Integrity In Children With Phenylketonuria, Erika M. Wesonga
Arts & Sciences Electronic Theses and Dissertations
Objective: Phenylketonuria (PKU) is a hereditary metabolic disorder associated with cognitive compromise. Diffusion tensor imaging (DTI) has allowed detection of poorer microstructural white matter integrity in children with PKU, with decreased mean diffusivity (MD) in comparison with healthy children. However, very little research has been conducted to examine the trajectory of white matter development in this population. The present study investigated potential differences in the developmental trajectory of MD between children with early- and continuously-treated PKU and healthy children across a range of brain regions.
Methods: Children with PKU (n = 31, mean age = 12.2 years) were …
Relationship Between Serum Biomarkers And Three-Month Outcomes Following Pediatric Traumatic Brain Injury (Tbi), Alicia Leanne Janos
Relationship Between Serum Biomarkers And Three-Month Outcomes Following Pediatric Traumatic Brain Injury (Tbi), Alicia Leanne Janos
Arts & Sciences Electronic Theses and Dissertations
With more than 475,000 cases annually, traumatic brain injury (TBI) is the leading cause of morbidity and mortality in children. Promising new tools for the prediction of functional outcomes following pediatric TBI are biomarkers of brain injury that can be detected in blood serum. The most commonly studied biomarkers, S100β, neuron-specific enolase (NSE), and myelin basic protein (MBP), have myriad limitations which preclude their use in clinical care. In the present study, serum concentrations of two novel biomarkers of brain injury (i.e., ubiquitin carboxy-terminal hydrolase-L1, UCH-L1; glial fibrillary acidic protein, GFAP) were collected 24 hours following severe TBI in 30 …