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Full-Text Articles in Psychology
Sex And Age Differences In Approach Behavior Toward A Port That Delivers Nicotine Vapor, Veronika Evangelina Espinoza
Sex And Age Differences In Approach Behavior Toward A Port That Delivers Nicotine Vapor, Veronika Evangelina Espinoza
Open Access Theses & Dissertations
The goal of our laboratory is to study the mechanisms that promote nicotine use, particularly in vulnerable populations such as adolescents and females. Thus, the purpose of this thesis was to characterize age and sex differences in the motivational/rewarding effects of nicotine (Aim 1) and withdrawal behavior (Aim 2). To more closely model human use patterns, the present study employed nicotine vapor methods involving passive exposure for 14 days in adolescent and adult female and male rats. Age and sex differences in approach behavior (nosepokes) were assessed in a port that delivered nicotine plumes on Day 1 and 14. Controls …
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Effects Of Repeated Nicotine Vapor Exposure And Withdrawal On Somatic Signs, Anxiety-Like Behavior, And Brain Reward Thresholds In Male Sprague Dawley Rats, Michelle Martinez
Open Access Theses & Dissertations
No abstract provided.
Examination Of Sex Differences And The Role Of Ovarian Hormones In Modulating Nicotine Withdrawal In Rats, Rodolfo Jesus Flores Garcia
Examination Of Sex Differences And The Role Of Ovarian Hormones In Modulating Nicotine Withdrawal In Rats, Rodolfo Jesus Flores Garcia
Open Access Theses & Dissertations
Introduction: Aim 1 characterized sex differences and the role of ovarian hormones in physical signs and negative affective states produced by nicotine withdrawal in female, ovariectomized female (OVX), and male rats. We also compared nicotine withdrawal and corticosterone levels with estradiol (E2) and progesterone across the 4-day estrous cycle. Aim 2 validated the role of ovarian hormones in withdrawal in OVX females that received vehicle, E2, or E2+progesterone. Methods: Female rats received a sham surgery or an ovariectomy procedure. Fifteen days later, all rats were implanted with a pump that delivered nicotine for 14 days. On the test day, separate …
Characterization Of Sex Differences In The Reinforcing Effects Of Nicotine, Rodolfo Jesus Flores Garcia
Characterization Of Sex Differences In The Reinforcing Effects Of Nicotine, Rodolfo Jesus Flores Garcia
Open Access Theses & Dissertations
It is presently unclear whether ovarian hormones, such as estradiol (E2) promote the reinforcing effects of nicotine in females. Thus, we compared extended access to nicotine intravenous self-administration (IVSA) in intact male, intact female, and OVX female rats (Study 1) as well as OVX females that received vehicle or E2 supplementation (Study 2). The E2 supplementation procedure involved a 4-day procedure involving 2 days of vehicle administration and 2 days of E2 administration. Two doses of E2 (25 or 250 ug) were assessed in separate groups of OVX females in order to examine the dose-dependent effects of this hormone on …
Characterization Of The Behavioral, Biochemical And Molecular Indices Of Stress Produced By Nicotine Exposure And Withdrawal In Male And Female Rats, Oscar Valentin Torres
Characterization Of The Behavioral, Biochemical And Molecular Indices Of Stress Produced By Nicotine Exposure And Withdrawal In Male And Female Rats, Oscar Valentin Torres
Open Access Theses & Dissertations
Introduction: Tobacco use is a major economic and health problem. Particularly concerning is that women consume more tobacco products, have a more difficult time quitting, and are less likely to benefit from cessation therapies than men. As a result, women are at higher risk of developing tobacco-related diseases. Women are generally more susceptible to stress and are more likely to cope with stress by smoking as compared to men. During abstinence, women also experience intense anxiety as compared to men and report that the anxiety-reducing effects of smoking are the main reason for continued use and relapse. Thus, stress produced …