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Hiv-1 And Cocaine: Motivation And Synaptic Function, Sarah J. Bertrand
Hiv-1 And Cocaine: Motivation And Synaptic Function, Sarah J. Bertrand
Theses and Dissertations
Molecular and behavioral assays were used to examine the effects of HIV-1 on synaptodendritic integrity, motivated behavior and the therapeutic potential of natural isoflavones in ameliorating both synaptodendritic injury in vitro and changes in motivation in vivo. The overarching hypothesis of the present dissertation is twofold: 1. HIV-1 causes a decrease in motivation for sucrose and cocaine and the change in motivational state is driven by compromised synaptic integrity as evaluated by F-actin and DAT function and, 2. Treatment with phytoestrogens will prevent synaptodendritic damage, normalize the internal motivational state of the HIV-1 Tg rat for sucrose and cocaine, and …