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Full-Text Articles in Psychology
Terminal Field Volume Of The Glossopharyngeal Nerve In Adult Rats Reverts To Prepruning Size Following Microglia Depletion With Plx5622, Andrew J. Riquier, Suzanne I. Sollars
Terminal Field Volume Of The Glossopharyngeal Nerve In Adult Rats Reverts To Prepruning Size Following Microglia Depletion With Plx5622, Andrew J. Riquier, Suzanne I. Sollars
Psychology Faculty Publications
Programmed reduction of synapses is a hallmark of the developing brain, with sensory systems emerging as useful models with which to study this pruning. The central projections (terminal field) of the gustatory glossopharyngeal nerve (GL) of the rat are a prime example of developmental pruning, undergoing an approximate 66% reduction in volume from postnatal day 15 (P15) to P25. Later in adulthood, developmental GL pruning can be experimentally reversed, expanding to preweaning volumes, suggesting mature volumes may be actively maintained throughout the life span. Microglia are central nervous system glia cells that perform pruning and maintenance functions in other sensory …
Astrocytic Response To Neural Injury Is Larger During Development Than In Adulthood And Is Not Predicated Upon The Presence Of Microglia, Andrew J. Riquier, Suzanne I. Sollars
Astrocytic Response To Neural Injury Is Larger During Development Than In Adulthood And Is Not Predicated Upon The Presence Of Microglia, Andrew J. Riquier, Suzanne I. Sollars
Psychology Faculty Publications
While contributions of microglia and astrocytes are regularly studied in various injury models, how these contributions differ across development remains less clear. We previously demonstrated developmental differences in microglial profiles across development in an injury model of the gustatory system. Nerves of the rat gustatory system have limited capacity to regenerate if injured during neonatal ages but show robust recovery if the injury occurs in adulthood. Using this developmentally disparate model of regenerative capacity, we quantified microglia and astrocytes in the rostral nucleus of the solitary tract (rNTS) following transection of the gustatory chorda tympani nerve (CTX) of neonatal and …
Regenerative Failure Following Rat Neonatal Chorda Tympani Transection Is Associated With Geniculate Ganglion Cell Loss And Terminal Field Plasticity In The Nucleus Of The Solitary Tract, Louis J. Martin, Amy H. Lane, Kaeli K. Samson, Suzanne I. Sollars
Regenerative Failure Following Rat Neonatal Chorda Tympani Transection Is Associated With Geniculate Ganglion Cell Loss And Terminal Field Plasticity In The Nucleus Of The Solitary Tract, Louis J. Martin, Amy H. Lane, Kaeli K. Samson, Suzanne I. Sollars
Psychology Faculty Publications
Neural insult during development results in recovery outcomes that vary dependent upon the system under investigation. Nerve regeneration does not occur if the rat gustatory chorda tympani nerve is sectioned (CTX) during neonatal (≤P10) development. It is unclear how chorda tympani soma and terminal fields are affected after neonatal CTX. The current study determined the impact of neonatal CTX on chorda tympani neurons and brainstem gustatory terminal fields. To assess terminal field volume in the nucleus of the solitary tract (NTS), rats received CTX at P5 or P10 followed by chorda tympani label, or glossopharyngeal (GL) and greater superficial petrosal …
Age-Related Decrease Of The Chorda Tympani Nerve Terminal Field In The Nucleus Of The Solitary Tract Is Prevented By Dietary Sodium Restriction During Development, Suzanne I. Sollars, B. R. Walker, A. K. Thaw, D. L. Hill
Age-Related Decrease Of The Chorda Tympani Nerve Terminal Field In The Nucleus Of The Solitary Tract Is Prevented By Dietary Sodium Restriction During Development, Suzanne I. Sollars, B. R. Walker, A. K. Thaw, D. L. Hill
Psychology Faculty Publications
Institution of a low-NaCl diet beginning at embryonic day 3 and continued throughout pre- and postnatal development has widespread effects on the neuroanatomical organization of the first gustatory relay in the nucleus of the solitary tract. To determine when these effects are expressed postnatally, the terminal field of the chorda tympani nerve was compared between sodium-restricted and sodium-replete rats at postnatal days 15–17, postnatal days 25–27, postnatal days 35–37, and adults. Total terminal fields were significantly larger in postnatal days 35–37 and adult sodium-restricted rats compared with aged-matched controls. The group-related differences appear related more to a remodeling of the …
Chorda Tympani Nerve Transection At Different Developmental Ages Produces Differential Effects On Taste Bud Volume And Papillae Morphology In The Rat, Suzanne I. Sollars
Chorda Tympani Nerve Transection At Different Developmental Ages Produces Differential Effects On Taste Bud Volume And Papillae Morphology In The Rat, Suzanne I. Sollars
Psychology Faculty Publications
Chorda tympani nerve transection (CTX) results in morphological changes to fungiform papillae and associated taste buds. When transection occurs during neonatal development in the rat, the effects on fungiform taste bud and papillae structure are markedly more severe than observed following a comparable surgery in the adult rat. The present study examined the potential “sensitive period” for morphological modifications to tongue epithelium following CTX. Rats received unilateral transection at 65, 30, 25, 20, 15, 10, or 5 days of age. With each descending age at the time of transection, the effects on the structural integrity of fungiform papillae were more …
Time Course Of Morphological Alterations Of Fungiform Papillae And Taste Buds Following Chorda Tympani Transection In Neonatal Rats, Suzanne I. Sollars, Peter C. Smith, David L. Hill
Time Course Of Morphological Alterations Of Fungiform Papillae And Taste Buds Following Chorda Tympani Transection In Neonatal Rats, Suzanne I. Sollars, Peter C. Smith, David L. Hill
Psychology Faculty Publications
The time course of structural changes in fungiform papillae was analyzed in rats that received unilateral chorda tympani nerve transection at 10 days of age. Morphological differences between intact and denervated sides of the tongue were first observed at 8 days postsection, with an increase in the number of fungiform papillae that did not have a pore. In addition, the first papilla with a filiform‐like appearance was noted on the denervated side at 8 days postsectioning. By 11 days after surgery, the total number of papillae and the number of papillae with a pore were significantly lower on the transected …