Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Psychology
Hiv Dna And Dementia In Treatment-Naïve Hiv-1-Infected Individuals In Bangkok, Thailand, Robert H. Paul, Bruce Shiramizu, Silvia Ratto-Kim, Pasiri Sithinamsuwan, Samart Nidhinandana, Sataporn Thitivichianlert, George Watt, Mark Desouza, Thippawan Chuenchitra, Suchitra Sukwit, Suwicha Chitpatima, Kevin Robertson, Cecilia M. Shikuma, Victor Valcour
Hiv Dna And Dementia In Treatment-Naïve Hiv-1-Infected Individuals In Bangkok, Thailand, Robert H. Paul, Bruce Shiramizu, Silvia Ratto-Kim, Pasiri Sithinamsuwan, Samart Nidhinandana, Sataporn Thitivichianlert, George Watt, Mark Desouza, Thippawan Chuenchitra, Suchitra Sukwit, Suwicha Chitpatima, Kevin Robertson, Cecilia M. Shikuma, Victor Valcour
Robert Paul
High HIV-1 DNA (HIV DNA) levels in peripheral blood mononuclear cells (PBMC) correlate with HIV-1-associated dementia (HAD) in patients on highly active antiretroviral therapy (HAART). If this relationship also exists among HAART-naïve patients, then HIV DNA may be implicated in the pathogenesis of HAD. In this study, we evaluated the relationship between HIV DNA and cognition in subjects naïve to HAART in a neuro AIDS cohort in Bangkok, Thailand. Subjects with and without HAD were recruited and matched for age, gender, education, and CD4 cell count. PBMC and cellular subsets were analyzed for HIV DNA using real-time PCR. The median …