Psychology Commons^™

Fkbp5 Modulates Attention Bias For Threat: Associations With Hippocampal Function And Morphology, Negar Fani, David Gutman, Erin Tone, Lynn Almli, Kristina B. Mercer, Jennifer Davis, Ebony Glover, Tanja Jovanovic, Bekh Bradley, Ivo D. Dinov, Alen Zamanyan, Arthur W. Toga, Elisabeth B. Binder, Kerry J. Ressler

Psychology Faculty Publications

Context: The FKBP5 gene product regulates glucocorticoid receptor (GR) sensitivity and hypothalamicpituitary‐adrenal axis functioning, and has been associated with a number of stress‐related psychiatric disorders. The study of intermediate phenotypes, such as emotion‐processing biases and their neural substrates, provides a way to clarify the mechanisms by which FKBP5 dysregulation mediates psychopathology risk.

Objective: To examine whether allelic variations for a putatively functional SNP associated with FKBP5 gene regulation (rs1360780) would relate differentially to attentional bias for threat; this was measured through behavioral response on a dot probe task and hippocampal activation during task performance. Morphological substrates of differential hippocampal response …

The Interplay Of Cognition And Cooperation, Sarah F. Brosnan, Lucie Salwiczek, Redouan Bshary

Psychology Faculty Publications

Cooperation often involves behaviours that reduce immediate payoffs for actors. Delayed benefits have often been argued to pose problems for the evolution of cooperation as learning such contingencies may be difficult as partners may cheat in return. Therefore, the ability to achieve stable cooperation has often been linked to a species’ cognitive abilities, which is in turn linked to the evolution of increasingly complex central nervous systems. However, in their famous 1981 paper, Axelrod & Hamilton stated that in principle even bacteria could play a tit for tat strategy in an iterated prisoner’s dilemma. While to our knowledge this has …

Introduction To Cooperation & Deception: From Evolution To Mechanisms, Sarah F. Brosnan, Redouan Bshary

Psychology Faculty Publications

Nature is full of struggle, as predicted by the theory of evolution through natural selection, yet there are also paramount examples where individuals help each other. These instances of helping have been difficult to reconcile with Darwin’s theory because it is not always obvious how individuals are working for their own direct benefit. Consequently, initial publications that offered solutions to subsets of the observed cases of helping, such as kin selection (Hamilton, 1964) or reciprocity (Axelrod & Hamilton, 1981; Trivers, 1971), are among the most influential and most cited papers in evolution / behavioural ecology. Despite these initial successes, models …

Neuroimmunoendocrine Pathology And Cognitive Function In Type 2 Diabetes, Krista Wild

Psychology Dissertations

Cognitive impairment among older adults with type 2 diabetes may worsen health outcomes via negative impact on compliance with medical self-care recommendations. Results of several previous studies indicate that cognitive deficits are present in older European American adults with type 2 diabetes under some conditions, particularly related to glucose dysregulation (as evidenced by high glycated hemoglobin, i.e., HbA1c). Despite the fact African Americans are disproportionately affected by diabetes and suffer significantly greater numbers of complications and more severe complications relative to European Americans, no published studies have examined cognitive functioning among older African American adults with type 2 diabetes. Further, …